8-azabicyclo[3.2.1]oct-2-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
The present invention relates to novel 8-azabicyclo[3.2.1]oct-2-ene derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
1. A compound of Formula I:
any of its enantiomers or any mixture of its enantiomers or a pharmaceutically acceptable salt thereof wherein
R 1 represents hydrogen or C 1-6 ˜alkyl; and
R 2 represents hydroxy.
2. The compound according to claim 1 , which is
(±)2-(8-Aza-bicyclo[3.2.1]oct-2-en-3-yl)-benzo[b]thiophen-5-ol; or
a pharmaceutically acceptable salt thereof.
3. A pharmaceutical composition comprising:
the compound according to claim 1 , any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically acceptable salt thereof; and
a pharmaceutically acceptable carrier, excipient or diluent.
4. The compound according to claim 1 , any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically acceptable salt thereof, for use as an inhibition of monoamine neurotransmitter re-uptake in a mammal, including a human.
5. A pharmaceutical composition, comprising a therapeutically effective amount of the compound of claim 2 , any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically acceptable salt thereof, together with at least one pharmaceutically acceptable carrier, excipient or diluent.