Coating for medical implants
A medical implant for drug delivery comprising an inner layer of polymer material including a drug dispersed therein and an outer layer which may then mediate the release of the drug in a controllable manner. The outer layer may adhere and/or penetrate the underlying layer and offer a protective coating along with improved mechanical strength along with the ability to hydrate and become permeable to water and allow for drug release.
1. A method for coating the surface of an implant comprising:
(a) exposing the implant surface to a silane coupling agent, wherein said implant surface is a metallic material;
(b) treating said implant surface with an aliphatic dialdehyde and bonding said dialdehyde to said silane coupling agent via imine functionality;
(c) coating the implant surface with a first layer of polymeric material that is covalently bound to the implant surface, wherein said first polymeric material includes one or more of the following: chitosan, chitin or gelatin;
(d) coating the first layer of polymeric material with a second layer of polymeric material wherein the second layer of polymeric material includes a drug for delivery and wherein said second layer of polymeric material is physically adhered to the first layer;
(e) coating the second layer with a third outer layer; and
(f) polymerizing said third outer layer,
wherein said third outer layer is joined to the second layer in the form of an interpenetrating polymer network wherein said second and third layers become interlaced and said third outer layer penetrates into said second layer 1.0 μm to 5.0 μm prior to polymerization,
wherein said third layer has higher mechanical strength than said first and second layers and is capable of hydration and said implant provides an initial cumulative drug release within 24 hours of administration of 0-95% and a sustained release of any remaining portion within a 14 day period.
2. The method of claim 1 wherein said first layer has a thickness of 10 nanometers to 100 nanometers.
3. The method of claim 1 wherein said second layer has a thickness of 100 nm to 500 μm.
4. The method of claim 1 wherein the outer layer of the implant comprises a polymer of the following formula:
wherein R1 is selected from a hydrogen, alkyl group and/or an aromatic ring;
R2 is selected from the group consisting of: (1) an alkyl group wherein at least one hydrogen on the alkyl group may be substituted with a hydrophilic type functional group; (2) ether and/or polyether type functionality.
5. The method of claim 4 wherein the polymer is poly-2-hydroxyethylmethacrylate and the value of n is greater than 34 to a value of 100.
6. The method of claim 1 wherein the surface of the implant includes a coupling agent to covalently bond said first layer to the surface of said implant.
7. The method of claim 1 wherein said outer layer is capable of absorbing 1.0% by weight to 50.0% by weight water.
8. The method of claim 1 wherein said metallic material is selected from the group consisting of Ti, Al, V, Cr, Fe, Co, Mo, Ni, Mn, Mg, Zr, and combinations thereof and/or stainless steels.
9. The method of claim 1 wherein said second layer comprises one or more of chitosan, collagen, gelatin, chitin, cellulose material, and/or PEG.
10. The method of claim 1 wherein said drug comprises an antibiotic, a statin, an anti-tumor agent, an anti-inflammatory agent; a therapeutic agent, an enzyme or cofactor; a cytokine; an anticoagulant; an immune system factor.
11. The method of claim 1 wherein said second layer and said outer layer have a thickness of 100 nm to 500 μm.
12. A method for coating the surface of an implant comprising:
(a) exposing the implant surface to a silane coupling agent, wherein said implant surface is a metallic material;
(b) treating said implant surface with an aliphatic dialdehyde and bonding said dialdehyde to said silane coupling agent via imine functionality;
(c) coating the implant surface with a first layer of polymeric material that is covalently bound to the implant surface by said coupling agent wherein said first polymer material includes surface functionality comprising amine, hydroxyl and/or carboxylic acid groups and includes one or more of the following: chitosan, chitin or gelatin;
(d) coating the first layer of polymeric material with a second layer of polymeric material wherein the second layer of polymeric material includes surface functionality comprising amine, hydroxyl and/or carboxylic acid and said second layer includes a drug for delivery and wherein said second layer of polymeric material is
physically adhered to the first layer;
(e) coating the second layer with a third outer layer; and
(f) polymerizing said third outer layer, wherein said third outer layer is joined to the second layer in the form of an interpenetrating polymer network wherein said second and third layers become interlaced, said third outer layer penetrates into said second layer 1.0 μm to 5.0 μm prior to polymerization and said third outer layer comprises:
wherein R1 is selected from a hydrogen, alkyl group and/or an aromatic ring;
R2 is selected from the group consisting of: (1) an alkyl group wherein at least one hydrogen on the alkyl group may be substituted with a hydrophilic type functional group; (2) ether and/or polyether type functionality.
13. The method of claim 12 wherein said first layer has a thickness of 10 nanometers to 100 nanometers.
14. The method of claim 12 wherein said second layer has a thickness of 100 nm to 500 μm.
15. The method of claim 12 wherein the polymer is poly-2-hydroxyethylmethacrylate and the value of n is greater than 34 to a value of 100.
16. The method of claim 12 wherein said outer layer is capable of absorbing 1% by weight to 50% by weight water.
17. The method of claim 12 wherein said metallic material is selected from the group consisting of Ti, Al, V, Cr, Fe, Co, Mo, Ni, Mn, Mg, Zr, and combinations thereof and/or stainless steels.
18. The method of claim 12 wherein said second layer comprises one or more of chitosan, collagen, gelatin, chitin, cellulose material, and/or PEG.
19. The method of claim 12 wherein said drug comprises an antibiotic, a statin, an anti-tumor agent, an anti-inflammatory agent; a therapeutic agent, an enzyme or cofactor; a cytokine; an anticoagulant; an immune system factor.
20. The method of claim 12 wherein said second layer and said outer layer have a thickness of 100 nm to 500 μm.
21. An implant comprising:
(a) an implant substrate including an outer surface wherein the implant is a metallic material selected from the group consisting of Ti, Al, V, Cr, Fe, Co, Mo, Ni, Mn, Mg, Zr, and combinations thereof and/or stainless steels wherein said metallic material has a surface having a silane coupling agent that is bonded to an aliphatic dialdehyde via imine functionality;
(b) a first layer of polymeric material that is covalently bound to the implant surface, wherein said first layer includes one or more of the following: chitosan, chitin or gelatin;
(c) a second layer of polymeric material wherein the second layer of polymeric material includes a drug for delivery and wherein said second layer of polymeric material is physically adhered to the first layer; and/or
(d) a third outer layer wherein said third outer layer is joined to the second layer in the form of an interpenetrating polymer network, wherein said second and third layers become interlaced and said third outer layer penetrates into said second layer at a depth of 1.0 μm to 5.0 μm prior to polymerization;
wherein said third layer has higher mechanical strength than said first and second layers and is capable of hydration and said implant provides an initial cumulative drug release within 24 hours of implantation of 0-95% and a sustained release of any remaining portion within a 14 day period.
22. An implant comprising:
(a) an implant substrate including an outer surface wherein the implant is a metallic material selected from the group consisting of Ti, Al, V, Cr, Fe, Co, Mo, Ni, Mn, Mg, Zr, and combinations thereof and/or stainless steels wherein said metallic material has a surface having a silane coupling agent that is bonded to an aliphatic dialdehyde via imine functionality;
(b) a first layer of polymeric material including a drug for delivery wherein said polymer material is covalently bound to the implant surface by said coupling agent wherein said first polymer material includes surface functionality comprising amine, hydroxyl and/or carboxylic acid groups;
(b) a second layer of polymeric material which includes surface functionality comprising amine, hydroxyl and/or carboxylic acid and said second layer includes a drug for delivery and wherein said second layer is physically adhered to the first layer;
(c) a third outer layer wherein said third outer layer is joined to the second layer in the form of an interpenetrating polymer network and wherein said second and third layers are interlaced and said third outer layer penetrates into said second layer 1.0 μm to 5.0 μm and said third outer layer comprises:
wherein R1 is selected from a hydrogen, alkyl group and/or an aromatic ring;
R2 is selected from: (1) an alkyl group wherein at least one hydrogen on the alkyl group may be substituted with a hydrophilic type functional group; (2) ether and/or polyether type functionality.