Durable biocides and disinfectants
Contemplated compositions and methods include a catechin at a concentration effective to inactivate SARS at least by a factor of 2 log 10 units when the formulation is applied to a surface. Preferably, the catechins are provided as a complex mixture, and most preferably as a near-native catechin preparation from green tea.
1. A method of reducing a number of infectious SARS viruses on a fomite surface comprising:
contacting the fomite surface with a composition that comprises a catechin preparation, wherein a plurality of infectious SARS viruses is present on the surface;
wherein the catechin preparation comprises at least one of (−)-Catechin Gallate, (−)-Epicatechin Gallate, (−)-Epigallocatechin Gallate, and (−)-Gallocatechin Gallate;
wherein the catechin preparation is present in the composition at a concentration effective to reduce via direct virucidal effect the number infectious SARS viruses at least by a factor of 2 log in units when the composition is applied to the plurality of infectious SARS viruses on the fomite surface.
2. The method of claim 1 wherein the fomite surface is a surface of a structure in contact with a non-human animal.
3. The method of claim 1 wherein the catechin preparation has a concentration of between 0.1 μM to about 100 μM in the composition.
4. The method of claim 1 wherein the fomite surface is a selected from the group consisting of a garment, a bedding, a protective device, a medical device, a cage, a rail, a fence, and a corral.
5. The method of claim 1 wherein the catechin preparation predominantly comprises at least one of an esterified catechin and a galloyl catechin.
6. The method of claim 1 wherein the catechin preparation comprises an ingredient selected from the group consisting of a green tea extract, a green tea extract powder, and a green tea concentrate.
7. The method of claim 1 wherein the step of contacting the surface comprises spraying the catechin preparation onto the surface.
8. The method of claim 1 wherein the catechin preparation is present at a concentration effective to reduce the number infectious SARS viruses at least by a factor of 3.5 log 10 units.
9. A method of reducing spread of SARS virus ex vivo comprising:
contacting ex vivo a virus carrier that comprises a plurality of infectious SARS viruses with a composition comprising a near-native catechin preparation from green tea,
wherein the composition comprises one or more of (−)-Catechin Gallate, (−)-Epicatechin Gallate, (−)-Epigallocatechin Gallate, (−)-Gallocatechin Gallate, free Theaflavin, and Theaflavindigallate;
wherein the catechin preparation is present at a concentration to inactivate SARS at least by a factor of 2 log 10 units via direct virucidal effect when the composition is applied to the plurality of infectious SARS viruses on the carrier; and
wherein the (−)-Catechin Gallate, (−)-Epicatechin Gallate, (−)-Epigallocatechin Gallate, (−) -Gallocatechin Gallate, free Theaflavin, and Theaflavindigallate are present in the composition at a concentration of between 0.1 μM to 100 μM.
10. The method of claim 9 wherein the near-native catechin preparation is selected from the group consisting of a green tea extract, a green tea extract powder, and a green tea concentrate.
11. The method of claim 10 wherein the catechin preparation is present at a concentration to inactivate SARS at least by a factor of 3.5 log 10 units.
12. The method of claim 9 wherein the virus carrier is an animal and wherein the step of contacting the carrier comprises spraying the catechin preparation onto the animal.
13. The method of claim 9 wherein the virus carrier is a surface in contact with an animal.
14. The method of claim 9 wherein the virus carrier is a surface that was previously exposed to a human infected with the SARS virus.
15. The method of claim 14 wherein the virus carrier is selected from the group consisting of a bedding surface, a garment surface, and a medical device surface.