Method for separating a substance from a fluid
This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
1. A method for separating a substance from a fluid, comprising the step of:
placing the fluid in contact with a composite material that displays a specific interaction for the substance, wherein the composite material comprises:
(a) a support member comprising a plurality of pores extending through the support member; and
(b) a non-self supporting macroporous cross-linked gel comprising macropores having an average size of 10 nm to 3000 nm, said macroporous gel being located in the pores of the support member;
wherein
said macroporous cross-linked gel is present in the pores of the support member in an amount sufficient such that, in use, liquid passing through the composite material passes through said macropores of said macroporous cross-linked gel;
said macropores of said macroporous cross-linked gel are smaller than said pores of said support member;
said macroporous cross-linked gel is a gel bearing a plurality of functional groups;
said functional groups are metal-affinity ligands; and
the substance is a metal-containing ion,
thereby adsorbing or absorbing the substance to the composite material.
2. The method of claim 1 , wherein the metal-containing ion comprises nickel cobalt, copper, and zinc.
3. The method of claim 1 , wherein the metal-containing ion comprises copper.
4. The method of claim 1 , wherein the fluid is an aqueous solution or mixture.