P53 peptide vaccine
The invention relates to a peptide derived from p53 that could be used as a vaccine against cancer.
1. A peptide composition comprising:
i) a peptide consisting of between 22 to 45 amino acids comprising between 22 to 30 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO: 4,
ii) a peptide consisting of between 22 to 45 amino acids, comprising between 22 to 30 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO: 5, and
iii) a peptide consisting of between 22 to 45 amino acids, comprising between 22 to 30 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO: 15.
2. The peptide composition of claim 1 , further comprising a peptide consisting of between 22 to 45 amino acids, comprising between 22 to 30 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO: 2, or a peptide consisting of between 22 to 45 amino acids, comprising between 22 to 30 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO: 20.
3. A peptide composition according to claim 1 , comprising:
i) a peptide consisting of between 22 to 45 contiguous p53 amino acids, comprising between 22 to 30 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO: 4,
ii) a peptide consisting of between 22 to 45 contiguous p53 amino acids, comprising between 22 to 30 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO: 5; and
iii) a peptide consisting of between 22 to 45 contiguous p53 amino acids, comprising between 22 to 30 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO: 15.
4. The peptide composition of claim 1 , 2 , or 3 further comprising a pharmaceutical excipient or an immune modulator.
5. The peptide composition according to claim 2 , further comprising a peptide consisting of between 22 to 45 contiguous p53 amino acids, comprising between 22 to 30 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO: 2, or a peptide consisting of between 22 to 45 contiguous p53 amino acids, comprising between 22 to 30 contiguous amino acids from the amino acid sequence set forth in SEQ ID NO: 20.