Treatment for age-related macular degeneration and other diseases of the eye
A method is disclosed for treating diseases or disorders of the eye involving undesired neovascularization by administration of a complement inhibitory protein such as soluble complement receptor type I (sCR1). The present invention relates to the direct treatment of macular degeneration, particularly age-related macular degeneration (AMD), by administering a complement inhibitory protein intraocularly or systemically.
1. A method for treating a disease of the eye characterized by undesired neovascularization in a mammalian subject comprising administering to a mammalian subject in need of treatment an effective amount of a complement inhibitory protein comprising a soluble complement receptor type I.
2. The method according to claim 1 , wherein said complement inhibitory protein is administered by an intraocular route.
3. The method according to claim 2 , wherein said intraocular administration is intravitreal administration.
4. The method according to claim 1 , wherein said complement inhibitory protein is administered by a intradermal, intramuscular, intraperitoneal, intravenous, subcutaneous, intrathecal, epidural, oral or pulmonary route.
5. The method of claim 1 , wherein said disease of the eye is age-related macular degeneration (AMD), diabetic retinopathy, corneal neovascularization, choroidal neovascularization, cyclitis, Hippel-Lindau Disease, retinopathy of prematurity, pterygium, histoplasmosis, iris neovascularization, macular edema, glaucoma-associated neovascularization, and Purtscher's retinopathy.
6. The method of claim 5 , wherein said disease of the eye is wet AMD.
7. The method of claim 5 , wherein said disease of the eye is dry AMD.
8. The method of claim 1 , wherein said soluble complement receptor type I is selected from the group consisting of: a soluble CR1 polypeptide having glycosylation modified to exhibit sialyl Lewis X moieties (sCR1-sLe x ), a soluble construct having two CR1 polypeptide moieties linked to an immunoglobulin Fc region (sCR1-F(ab) 2 fusion), a soluble CR1 polypeptide comprising the extracellular domain of mature human CR1 (SEQ ID NO:3), and a soluble CR1 polypeptide as expressed by Chinese hamster ovary DUX B11 cells as deposited under ATCC accession no. CRL 10052.
9. The method of claim 1 , wherein said soluble complement receptor type I is a soluble CR1 polypeptide comprising the extracellular domain of mature human CR1 (SEQ ID NO:3).
10. The method of claim 5 , wherein said subject is a human, said soluble complement receptor type I is a soluble CR1 polypeptide comprising the extracellular domain of mature human CR1 (SEQ ID NO:3), said disease of the eye is age-related macular degeneration (AMD), and said administering is systemic administration.
11. The method of claim 10 , wherein said human subject is administered an amount of soluble complement receptor type I of 0.1-10 mg/kg body weight.
12. The method of claim 5 , wherein said subject is a human, said soluble complement receptor type I is a soluble CR1 polypeptide comprising the extracellular domain of mature human CR1 (SEQ ID NO:3), said disease of the eye is age-related macular degeneration (AMD), and said administering is intraocular.
13. The method of claim 12 , wherein said human subject is administered an amount of soluble complement receptor type I of 5-10,000 μg/eye.