Specific salt, anhydrous and crystalline form of a dihydropteridione derivative

Inventors: Guenter Linz (Mittelbiberach, DE); Peter Sieger (Mittelbiberach, DE); Matthias Grauert (Biberach an der Riss, DE); Rolf Schmid (Baltringen, DE)

Assignee: Boehringer Ingelheim International GmbH

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Quick Facts

Patent No.: US 8,664,222
App. No.: 13/457,991
Granted: Mar 4, 2014
Kind: B2

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Abstract

The present invention relates to a specific salt of a dihydropteridione derivative, namely the trihydrochloride salt of the compound N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide, to its crystallization in the form of an hydrate with water, to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.

Claims (2)

1. Anhydrous form of the trihydrochloride salt of N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide.

2. Crystalline, anhydrous form of the trihydrochloride salt of N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide.

Assignments (1)

CONFIRMATORY LICENSE Recorded May 21, 2020

From: BOEHRINGER INGELHEIM PHARMA GMBH

To: ONCOHEROES BIOSCIENCES INC.

Reel/Frame 052722/0909 →

Priority Claims (1)

EP 06101414 · Feb 8, 2006 · regional

Continuity (3)

Continuation 12212188 · Sep 17, 2008

Continuation 11668681 · Jan 30, 2007

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