Chemical compounds

1. A compound of formula (I)

or a salt thereof, wherein

X and Y are each independently C or N;

X and Y are not both N;

R 1 is —CN;

R 2 is halogen;

R 3 is C 1-6 alkyl or C 1-3 haloalkyl;

R 4 is (R 8 )(R 9 );

R 5 is H;

R 8 is C 1-6 alkylene;

R 9 is oxadiazolyl, wherein said oxadiazolyl is optionally substituted with one or more substituents independently selected from R a and R b ; wherein

R a is CN, —C(O)R 6 , —NR 12 R 13 , C 1-6 alkyl, C 3-6 cycloalkyl, C 1-3 haloalkyl, halogen, or heterocyclyl, wherein said heterocyclyl is optionally substituted with one or more substituents independently selected from halogen, CN, C 1-6 alkyl, C 1-3 haloalkyl, —SCH 3 , and —S(O) 2 CH 3 ;

R b is phenyl optionally substituted with one or more substitutents independently selected from —OH, halogen, C 1-6 alkyl, C 1-3 haloalkyl, C 1-3 haloalkoxy, CN, nitro, C 1-3 alkoxy,

C 3-6 cycloalkyl, heterocyclyl, —C(O)OCH 3 , —SCH 3 , —C(O)OH, —C(O)NR 12 R 13 , —S(O) 2 CH 3 , and

—C(O)CH 3 ;

R 12 and R 13 are each independently selected from H and C 1-6 alkyl;

m is 0 or 1;

p is 0 or 1;

when Y is N, m is 0; and

when X is N, p is 0.

2. A compound as claimed in claim 1 wherein R 2 is —Cl.

3. A compound as claimed in claim 1 wherein X and Y are both C.

4. A compound as claimed in claim 1 wherein R 3 is C 1-6 alkyl.

5. A compound as claimed in claim 1 wherein R 8 is C 1-2 alkylene.

6. The compound of claim 5 wherein R 8 is methylene.

7. The compound of claim 1 wherein R a is heterocyclyl substituted with one or more halogens.

8. The compound of claim 1 wherein R b is phenyl substituted with one or more substituents independently selected from C 1-3 haloalkyl, CN, or halogen.

9. The compound of claim 1 where R 3 is CF 3 .

10. The compound of claim 1 wherein said phenyl is substituted with is CF 3 .

11. A compound as claimed in claim 1 , selected from the group consisting of:

4-Chloro-2-(difluoromethyl)-1-{[5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-1H-indole-5-carbonitrile;

4-Chloro-2-(difluoromethyl)-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-indole-5-carbonitrile;

1-{[5-(5-Bromo-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile;

4-Chloro-1-{[5-(5-cyano-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-(difluoromethyl)-1H-indole-5-carbonitrile;

4-Chloro-2-(difluoromethyl)-1-{[5-(2-pyridinyl)-1,2,4-oxadiazol-3-yl]methyl}-1H-indole-5-carbonitrile;

1-{[5-(5-Bromo-3-pyridinyl)-1,2,4-oxadiazol-3-yl]methyl}-4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile;

4-Chloro-2-(difluoromethyl)-1-{[5-(2,4-difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-1H-indole-5-carbonitrile;

4-Chloro-2-(difluoromethyl)-1-{[5-(2,4-difluorophenyl)-1,3,4-oxadiazol-2-yl]methyl}-1H-indole-5-carbonitrile;

4-Chloro-2-(difluoromethyl)-1-{[5-(3,5-difluorophenyl)-1,3,4-oxadiazol-2-yl]methyl}-1H-indole-5-carbonitrile;

4-Chloro-2-(difluoromethyl)-1-{[3-(2-pyridinyl)-1,2,4-oxadiazol-5-yl]methyl}-1H-indole-5-carbonitrile;

4-Chloro-2-(difluoromethyl)-1-{[5-(6-fluoro-2-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-1H-indole-5-carbonitrile;

4-Chloro-2-(difluoromethyl)-1-{[5-(3,5-dimethyl-4-isoxazolyl)-1,2,4-oxadiazol-3-yl]methyl}-1H-indole-5-carbonitrile;

4-Chloro-2-(difluoromethyl)-1-(1,3-thiazol-4-ylmethyl)-1H-indole-5-carbonitrile;

1-({5-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile;

4-Chloro-2-(difluoromethyl)-1-{[5-(trifluoromethyl)-2-furanyl]methyl}-1H-indole-5-carbonitrile;

4-Chloro-2-(difluoromethyl)-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-2,3-dihydro-1H-indole-5-carbonitrile;

4-Chloro-2-ethyl-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-benzimidazole-5-carbonitrile;

4-Chloro-1-{[5-(3,5-dimethyl-4-isoxazolyl)-1,2,4-oxadiazol-3-yl]methyl}-2-ethyl-1H-benzimidazole-5-carbonitrile;

1-({5-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-chloro-2-ethyl-1H-benzimidazole-5-carbonitrile;

4-Chloro-2-ethyl-1-{[5-(2-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-1H-benzimidazole-5-carbonitrile;

4-Chloro-2-ethyl-1-({5-[6-(trifluoromethyl)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)-1H-benzimidazole-5-carbonitrile;

4-Chloro-1-{[5-(2-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-(trifluoromethyl)-1H-benzimidazole-5-carbonitrile;

and salts thereof.

12. A compound as claimed in claim 1 , selected from the group consisting of:

4-Chloro-2-propyl-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-indole-5-carbonitrile;

4-Chloro-1-{[5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-propyl-1H-indole-5-carbonitrile;

1-{[5-(5-Bromo-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-4-chloro-2-propyl-1H-indole-5-carbonitrile;

4-Chloro-2-methyl-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-1H-indole-5-carbonitrile;

4-Chloro-1-{[5-(3,5-difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-methyl-1H-indole-5-carbonitrile;

1-{[5-(5-Bromo-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-4-chloro-2-methyl-1H-indole-5-carbonitrile;

1-({5-[3,5-bis(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-chloro-2-propyl-1H-indole-5-carbonitrile;

1-({5-[3,5-bis(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-chloro-2-methyl-1H-indole-5-carbonitrile;

4-Chloro-1-{[5-(3,5-dimethyl-4-isoxazolyl)-1,2,4-oxadiazol-3-yl]methyl}-2-methyl-1H-indole-5-carbonitrile;

1-({5-[3,5-bis(Trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-4-chloro-2-(trifluoromethyl)-1H-indole-5-carbonitrile;

4-Chloro-1-{[5-(3,5-dimethyl-4-isoxazolyl)-1,2,4-oxadiazol-3-yl]methyl}-2-(trifluoromethyl)-1H-indole-5-carbonitrile;

4-Chloro-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}methyl)-2-(3,3,3-trifluoropropyl)-1H-indole-5-carbonitrile;

4-Chloro-1-{[5-(2,6-dichloro-4-pyridinyl)-1,2,4-oxadiazol-3-yl]methyl}-2-propyl-1H-indole-5-carbonitrile;

4-Chloro-1-({5-[3-methyl-5-(trifluoromethyl)-4-isoxazolyl]-1,2,4-oxadiazol-3-yl}methyl)-2-propyl-1H-indole-5-carbonitrile;

4-Chloro-1-{[5-(1,3-dimethyl-1H-pyrazol-5-yl)-1,2,4-oxadiazol-3-yl]methyl}-2-propyl-1H-indole-5-carbonitrile;

4-Chloro-1-({5-[5-chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1,2,4-oxadiazol-3-yl}methyl)-2-propyl-1H-indole-5-carbonitrile;

4-Chloro-1-({5-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]-1,2,4-oxadiazol-3-yl}methyl)-2-propyl-1H-indole-5-carbonitrile;

4-Chloro-1-({5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-1,2,4-oxadiazol-3-yl}methyl)-2-propyl-1H-indole-5-carbonitrile;

and salts.

13. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier.

14. A pharmaceutical composition comprising a compound according to claim 11 and a pharmaceutically acceptable carrier.

15. A pharmaceutical composition comprising a compound according to claim 12 and a pharmaceutically acceptable carrier.