Extended release biodegradable ocular implants
Biodegradable implants sized and suitable for implantation in an ocular region or site and methods for treating ocular conditions. The implants provide an extended release of an active agent at a therapeutically effective amount for a period of time between 50 days and one year, or longer.
1. A drug delivery system for treating an ocular condition, the drug delivery system comprising first, second, and third bioerodible implants suitable for insertion into an ocular region or site,
the first bioerodible implant comprising dexamethasone and a poly(D,L-lactide) having an average molecular weight of about 3,500 Daltons;
the second bioerodible implant comprising dexamethasone and a poly(D,L-lactide-co-glycolide) having a 75:25 wt %/wt % blend of lactide:glycolide and an average molecular weight of about 40,000 Daltons; and
the third bioerodible implant comprising dexamethasone and a poly(D,L-lactide) having an average molecular weight of about 14,000 Daltons,
wherein the drug delivery system, when inserted into an ocular region or site, can release a therapeutic level of dexamethasone into the ocular region or site for a period of time between about 30 days and about 1 year.
2. The drug delivery system according to claim 1 , wherein each of the first, second, and third implants is an extruded implant weighing about 1 mg and containing about 50% by weight dexamethasone.