Anti-infective agents and uses thereof
The present invention is concerned with novel immunostimulant microparticle compositions and their use as anti-infective agents in the treatment of bacterial and viral infections.
1. A method of therapeutic treatment of an infection in a subject caused by a virus and/or a bacterium, comprising administering to the subject an effective amount of an MDP/DNA-microparticle, wherein the MDP/DNA-microparticle does not compromise a viral and/or bacterial antigen, and wherein the MDP/DNA-microparticle activates an innate immune response.
2. A method according to claim 1 , wherein the innate immune response includes activation of NK cells, plasmocytoid dendritic cells (pDC) and/or monocytes.
3. A method according to claim 1 , wherein the MDP/DNA-microparticle further induces and/or stimulates the release of at least one cytokine.
4. A method according to claim 3 , wherein the cytokine is selected from interferon-alpha (IFN-α), interferon gamma (IFN-γ), interleukin 10 (IL-10), interleukin 6 (IL-6), interleukin 1-beta (IL-1β), tumour necrosis factor alpha (TNF-α), interleukin 12 (IL-12), and/or CD8 antiviral factor.
5. A method according to claim 1 , wherein the MDP/DNA-microparticle comprises at least one immunostimulatory ligand.
6. A method according to claim 5 , wherein the ligand is selected from TLR1,2,3,4,5,6,7,8,9,10, NOD-1 and/or NOD-2.
7. A method according to claim 1 , further comprising administering another therapeutic agent effective in the treatment of an infection caused by a virus and/or bacterium.
8. A method according to claim 7 , wherein the another therapeutic agent is a vaccine and/or and antibiotic that is administered simultaneously or sequentially.
9. A method according to claim 1 , wherein the subject is a mammal.
10. A method according to claim 1 , wherein the infection to be treated is selected from influenza, plague or tuberculosis.