Use of natriuretic peptide for treating heart failure
The present invention relates to the use of a natriurectic peptide, such as urodilatin, for treating a patient suffering from heart failure, such as acute decompensated heart failure. Preferably, a composition comprising an effective amount of urodilatin is intravenously administered to the patient continuously through a time period of at least 24 hours and up to 120 hours, preferably at least 48 hours.
1. A method for treating acute decompensated heart failure (ADHF) or decompensated heart failure (DHF) in a patient, comprising administering continuously for a time period of at least 24 hours to the patient, a composition comprising an effective amount of urodilatin, wherein the patient exhibits improvement in an ADHF or DHF related parameter which is pulmonary capillary wedge pressure and the patient exhibits improvement in ADHF or DHF related dyspnea.
2. The method of claim 1 , wherein the composition is administered intravenously.
3. The method of claim 1 , wherein the time period is between 24 to 120 hours.
4. The method of claim 1 , wherein the time period is between 24 to 96 hours.
5. The method of claim 1 , wherein the time period is between 24 to 72 hours.
6. The method of claim 1 , wherein the time period is between 24 to 48 hours.
7. The method of claim 1 , wherein the time period is between 48 to 72 hours.
8. The method of claim 1 , wherein the time period is between 48 to 96 hours.
9. The method of claim 1 , wherein the time period is between 72 to 96 hours.
10. The method of claim 1 , wherein the time period is between 72 to 120 hours.
11. The method of claim 1 , wherein the time period is between 96 to 120 hours.
12. The method of claim 2 , wherein urodilatin is administered at the rate of at least 7.5 ng/(kg·min).
13. The method of claim 12 , wherein urodilatin is administered at the rate of 7.5 ng/(kg·min).
14. The method of claim 12 , wherein urodilatin is administered at the rate of 15 ng/(kg·min).
15. The method of claim 12 , wherein urodilatin is administered at the rate of 30 ng/(kg·min).
16. The method of claim 12 , wherein urodilatin is administered at the rate of 45 ng/(kg·min).
17. The method of claim 12 , wherein urodilatin is administered at the rate of 60 ng/(kg·min).
18. The method of claim 12 , wherein urodilatin is administered at the rate of 100 ng/(kg·min).
19. The method of claim 12 , wherein urodilatin is administered at the rate of 200 ng/(kg·min).
20. The method of claim 1 , wherein the composition further comprises mannitol.
21. The method of claim 20 , wherein the concentration of mannitol in the composition is 10 times the concentration of urodilatin.
22. The method of claim 20 , wherein the composition is an aqueous solution of 0.9% NaCl in which urodilatin and mannitol are dissolved.
23. The method of claim 1 , further comprising administering to the patient an effective amount of one or more different cardiac medicines.
24. The method of claim 1 , wherein the time period is 24 hours.
25. The method of claim 1 , wherein the time period is 48 hours.
26. The method of claim 1 , wherein the time period is 72 hours.
27. The method of claim 1 , wherein the time period is 96 hours.
28. The method of claim 1 , wherein the time period is 120 hours.