Multicyclic compounds and methods of use thereof
Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
1. A compound of formula (IVa):
or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:
m is 0;
n is 1;
R 1 and R 2 are each independently hydrogen or C 1 -C 4 alkyl;
R 3 and R 4 are each independently hydrogen or C 1 -C 4 alkyl;
R 5 is hydrogen; and
R 6 and R 7 are each independently hydrogen, halo, or C 1 -C 4 alkyl.
2. The compound of claim 1 , or a pharmaceutically acceptable salt or stereoisomer thereof, wherein R 3 and R 4 are each hydrogen and R 6 and R 7 are each independently hydrogen, or C 1 -C 4 alkyl.
3. The compound of claim 1 wherein the compound is:
or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
7. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
8. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
9. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
10. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
11. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
12. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
13. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
14. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
15. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
16. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
17. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
18. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
19. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
20. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
21. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
22. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
23. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
24. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
25. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
26. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
27. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
28. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
29. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
30. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
31. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
32. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
33. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
34. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
35. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
36. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
37. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
38. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
39. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
40. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
41. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.