Truncated secretory aspartyl proteinase 2
The present invention relates to an isolated truncated form of the secretory aspartyl proteinase 2, as well as to nucleic acid molecules encoding same. The present invention also relates to a composition comprising an isolated truncated form of the secretory aspartyl proteinase 2, as well as to nucleic acid molecules encoding same.
1. An isolated polypeptide consisting of
the amino acid sequence of SEQ ID NO:1.
2. A composition comprising the isolate polypeptide of claim 1 .
3. A vaccine composition against Candida albicans comprising:
an isolated polypeptide consisting of the amino acid sequence of SEQ ID NO: 1.
4. The vaccine composition of claim 3 , further comprising one or more additional components selected from the group consisting of excipients, diluents, adjuvants, and delivery vehicles.
5. A method of eliciting an immune response against Candida albicans in a mammal, wherein the method comprises administering to the mammal a composition comprising the isolated polypeptide of claim 1 .
6. The method of claim 5 , wherein the composition further comprises one or more additional components selected from the group consisting of excipients, diluents, adjuvants, and delivery vehicles.
7. The method of claim 6 , wherein the delivery vehicle is a virosome.
8. The method of claim 7 , wherein the isolated polypeptide is linked to the surface of the virosome.
9. The method of claim 7 , wherein the isolated polypeptide is contained in the lumen of the virosome.
10. The method claim 9 , wherein the isolated polypeptide is both linked to the surface of and contained in the lumen of the virosome.
11. A kit comprising
an isolated polypeptide consisting of the amino acid sequence of SEQ ID NO: 1.