Combination of pilocarpin and methimazol for treating Charcot-Marietooth disease and related disorders
The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related peripheral neuropathies. More particularly, the invention relates to combined therapies for treating said disease by affecting simultaneously muscarinic receptor signaling and thyroid hormone pathway in a subject.
1. A method of treating Charcot-Marie-Tooth (CMT) disease in a subject in need thereof comprising the administration to said subject of a combination product or composition comprising:
(i) pilocarpine or a salt thereof;
(ii) methimazole, carbimazole, or a salt thereof; and
(iii) a pharmaceutically acceptable carrier or excipient.
2. The method of claim 1 , wherein said combination product comprises:
a) a salt of methimazole and a salt of pilocarpine;
b) a salt of methimazole and pilocarpine;
c) methimizole and pilocarpine;
d) methimizole and a salt of pilocarpine;
e) carbimazole and pilocarpine;
f) carbimazole and a salt of pilocarpine;
g) a salt of carbimazole and pilocarpine; or
h) a salt of carbimazole and a salt of pilocarpine.
3. The method of claim 1 , said combination product or composition further comprising at least one additional active compound.
4. The method of claim 3 , wherein said at least one additional active compound is selected from baclofen, mifepristone, sorbitol, naltrexone, rapamycin, ketoprofen or flurbiprofen, or salts thereof.
5. The method of claim 4 , wherein said at least one additional compound is baclofen or mifepristone, or salts thereof.
6. The method of claim 2 , wherein said combination product comprises a salt of methimazole and a salt of pilocarpine.
7. The method of claim 2 , wherein said combination product comprises a salt of methimazole and pilocarpine.
8. The method of claim 2 , wherein said combination product comprises methimizole and pilocarpine.
9. The method of claim 2 , wherein said combination product comprises methimizole and a salt of pilocarpine.
10. The method of claim 2 , wherein said combination product comprises carbimazole and pilocarpine.
11. The method of claim 2 , wherein said combination product comprises carbimazole and a salt of pilocarpine.
12. The method of claim 2 , wherein said combination product comprises a salt of carbimazole and pilocarpine.
13. The method of claim 2 , wherein said combination product comprises a salt of carbimazole and a salt of pilocarpine.