Physically/molecularly distributed and/or chemically bound medicaments in empty, hard capsule shells
View Patent ↗The present invention incorporates medicaments in the empty hard capsule shells (body and cap). The medicament is either physically/molecularly distributed and/or chemically bound to the polymer matrix of the capsule shell composition. Other medicaments in the form of drug-loaded matrices (powders, granules, beads, pellets, mini-tablets, and mini-capsules) can be filled in the drug-loaded empty, hard capsule shells. The same capsule dosage form contains medicaments in the core matrix and in the shell.
1. A hard-shell capsule comprising:
a body, a cap, a first drug, and a second drug;
the body and the cap cooperatively defining a hollow capsule; and
the first drug being dispersed only throughout the cap and the second drug being dispersed only throughout the body.
2. The hard-shell capsule of claim 1 wherein at least one of the said cap and said body comprises a composition and the drug is physically disbursed throughout the composition.
3. The hard-shell capsule of claim 1 wherein at least one of the said cap and said body comprises a composition and the drug is chemically bonded with said composition.
4. The hard-shell capsule of claim 1 wherein at least one of the said body and said cap is manufactured by a pin dipping technique wherein a pin is dipped into a liquid.