Noggin-derived peptide and use thereof
Disclosed are a noggin-derived peptide and a composition containing the same for promoting hair growth, improving skin conditions, providing anti-inflammatory function, or preventing or treating bone diseases. The disclosed noggin-derived peptide performs a function identical or similar to that of natural human noggin and is superior in stability and skin permeability as compared thereto. The composition containing the peptide of the present disclosure as an active ingredient exhibits remarkably superior effects in treating, preventing or improving growth factor-related symptoms, e.g. hair loss, skin conditions or cut, or treating, preventing or improving growth factor overexpression-related symptoms. Therefore, the superior activity and stability of the peptide of the present disclosure are greatly advantageous in application to medicine, quasi-drugs and cosmetics.
1. A peptide comprising the amino acid sequence of the general formula (1): SEQ ID NO:2-linker-SEQ ID NO:3 (1)
wherein the linker comprises Xaa(n); Xaa is any amino acid; and n is an integer of 2-18;
wherein the peptide exhibits an antagonistic activity against bone morphogenetic protein (BMP)-2, BMP-4 or BMP-7 by binding to BMP-2, BMP-4 or BMP-7.
2. The peptide according to claim 1 , wherein the linker comprises 2 to 10 Gly residues.
3. The peptide according to claim 1 , wherein the peptide has an ability to promote the growth of keratinocytes or fibroblasts.
4. The peptide according to claim 1 , wherein the peptide promotes the production of laminin or hyaluronic acid in fibroblasts.
5. A composition comprising the peptide according to claim 1 as an active ingredient.
6. A method for promoting hair growth, comprising administering to a subject in need thereof a composition comprising the peptide according to claim 1 as an active ingredient.