Methods for optimization of biventricular pacing devices and systems useful therefor
The invention is directed to methods and devices for optimization of biventricular pacing in subjects suffering from heart failure. The invention provides for a method for selection of optimal parameters for permanent pacing, the method comprising: positioning one or more arrays of lead wires in the posterior pericardium of a subject, wherein the arrays are connected to a multiplexing switch, wherein the switch is connected to a computer processor and a biventricular pacemaker; from the computer processor, generating a randomized sequence of: (i) pacing sites (VPS), (ii) right ventricular-left ventricular delays (RLDs), (iii) heart rates (HR); (iv) atrioventricular delays (AVDs), (v) or any combination or permutation thereof; and determining cardiac output in real time, using aortic flow velocity, thereby allowing selection of optimal parameters for permanent pacing.
1. A method for selection of optimal parameters for permanent pacing, the method comprising:
(a) positioning one or more arrays of lead wires in the posterior pericardium of a subject, wherein the arrays are connected to a multiplexing switch, wherein the switch is connected to a computer processor and a biventricular pacemaker;
(b) from the computer processor, generating a randomized sequence of: (i) pacing sites (VPS), (ii) right ventricular-left ventricular delays (RLDs), (iii) heart rates (HR); (iv) atrioventricular delays (AVDs), (v) or any combination or permutation thereof; and
(c) determining cardiac output in real time, using aortic flow velocity, thereby allowing selection of optimal parameters for permanent pacing.
2. The method of claim 1 , wherein the processor automatically implements the randomized sequence of VPS/RLD/HRJAVD combinations while recording aortic flow_via the aortic flow probe.
3. The method of claim 1 , wherein the computer processor selects a parameter combination producing the highest cardiac output.
4. The method of claim 1 , further comprising displaying results regarding parameter combinations for permanent pacing.
5. The method of claim 1 , wherein a heart rate permutation is from about 60 to about 100 beats per minute.
6. The method of claim 1 , wherein an AVD permutation is from about 90 to about 300 msec.
7. The system of claim 1 , wherein a RLD permutation is from about −80 to about +80 msec.