IP Library › Granted Patent US 8,747,869
Granted Patent B2
US 8,747,869 · App. 13/052,067 · Granted Jun 10, 2014

Lipid vesicle compositions and methods of use

Inventors: Darrell J. Irvine (Arlington, MA); Jaehyun Moon (Cambridge, MA)
Assignee: Massachusetts Institute of Technology
A61K9/127A61K2039/55572A61K9/1273
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Quick Facts
Patent No.
US 8,747,869
App. No.
13/052,067
Granted
Jun 10, 2014
Kind
B2
Abstract

The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

Claims (15)

1. A multilamellar lipid vesicle having covalent crosslinks between lipid bilayers, wherein at least two lipid bilayers in the multilamellar lipid vesicle are covalently crosslinked to each other through headgroups that react with covalent crosslinkers to form the covalent crosslinks between lipid bilayers.

2. The multilamellar lipid vesicle of claim 1 , wherein the vesicle comprises phosphocholine.

3. The multilamellar lipid vesicle of claim 1 , wherein the vesicle comprises phosphoglycerol.

4. The multilamellar lipid vesicle of claim 1 , wherein the headgroups are maleimide headgroups.

5. The multilamellar lipid vesicle of claim 1 , wherein the vesicle comprises an antigen.

6. The multilamellar lipid vesicle of claim 1 , wherein the vesicle comprises an adjuvant.

7. The multilamellar lipid vesicle of claim 1 , wherein the vesicle comprises a protein.

8. The multilamellar lipid vesicle of claim 1 , wherein the vesicle comprises an agent encapsulated within the vesicle.

9. The multilamellar lipid vesicle of claim 1 , wherein the vesicle comprises an agent encapsulated between the lipid bilayers.

10. The multilamellar lipid vesicle of claim 1 , wherein the vesicle is conjugated to polyethylene glycol (PEG).

11. The multilamellar lipid vesicle of claim 1 , wherein the vesicle comprises DOPC, DOPG and a maleimide functionalized lipid.

12. The multilamellar lipid vesicle of claim 11 , wherein the maleimide functionalized lipid is a maleimide functionalized phosphoethanolamine.

13. A composition comprising the multilamellar lipid vesicle of claim 1 and a pharmaceutically acceptable carrier.

14. A composition comprising the multilamellar lipid vesicle of claim 1 and an excipient suitable for lyophilization.

15. A composition comprising the multilamellar lipid vesicle of claim 14 , wherein the excipient suitable for lyophilization comprises sucrose.

Assignments (5)
APPOINTMENT OF INVESTIGATOR AS AGENT Recorded Aug 20, 2015
From: HOWARD HUGHES MEDICAL INSTITUTE
To: IRVINE, DARRELL
Reel/Frame 036407/0424 →
CONFIRMATORY LICENSE Recorded Dec 9, 2011
From: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 027357/0921 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 19, 2011
From: MOON, JAEHYUN
To: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Reel/Frame 026615/0419 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 24, 2011
From: HOWARD HUGHES MEDICAL INSTITUTE
To: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Reel/Frame 026329/0932 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 4, 2011
From: IRVINE, DARRELL
To: HOWARD HUGHES MEDICAL INSTITUTE
Reel/Frame 026070/0319 →
Continuity (3)
Provisional Application 61315485 · Mar 19, 2010
Provisional Application 61319709 · Mar 31, 2010
Related Publication 20110229529A1 · Sep 22, 2011