Local system for the release of active principle and process for its manufacture
A local system for the release of active principle is described which consists of approximately spherical or rotation symmetrical bodies which are composed essentially of polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate, zirconium dioxide or barium sulphate and one or more pharmaceutical active principles, in particular antibiotics, and which are produced by radical polymerization, radical polymerization activators effective in the temperature range of 10-80° C. or residues of these polymerization activators from the groups of aromatic amines, heavy metal salts and barbiturates not being contained therein. A process for the production of the local system for the release of active principle in the case of which a) a paste is produced by mixing methyl methacrylate, polymethyl methacrylate or polymethyl methacrylate co-methyl acrylate, zirconium dioxide and/or barium sulphate, one or more pharmaceutical active principles and a thermally decomposing radical initiator, the paste having a viscosity such that it cannot be deformed at room temperature by the effect of gravity; b) the paste is injection molded by an injection molding device without heating at room temperature into approximately spherical or rotation-symmetrical bodies or the approximately spherical or rotation symmetrical bodies are injection-molded onto a wire; c) the bodies are heated to a temperature at which the polymerization initiator decomposes.
1. Process for the production of a local system for the release of an active principle which consists of spherical or rotationally symmetrical bodies which are composed essentially of
i) polymethyl methacrylate and polymethyl methacrylate co-methyl acrylate,
ii) zirconium dioxide and/or barium sulphate, and
iii) one or more pharmaceutically active principles, said local system not containing radical polymerization activators which are effective in the temperature range of 10-80° C. selected from the group consisting of aromatic amines, heavy metal salts and barbiturates, or residues thereof, by local polymerization, which comprises
a) producing a paste by mixing
methyl methacrylate,
optionally polymethyl methacrylate,
polymethyl methacrylate co-methyl acrylate,
zirconium dioxide and/or barium sulphate,
one or more pharmaceutical active principles, and
a thermally decomposing radical initiator,
the paste having a viscosity sufficient to prevent deformation at room temperature by the effect of gravity;
b) injection moulding the paste by an injection moulding device into spherical or rotationally symmetrical bodies or injection moulding spherical or rotationally-symmetrical bodies onto a wire;
c) heating the bodies to a temperature at which the thermally decomposing radical initiator decomposes and polymerizing the methyl methacrylate.
2. Process according to claim 1 , wherein in step c) heating is by infrared radiation, hot air or microwaves.
3. Process according to claim 1 , wherein the decomposing radical initiator is one or more of the substances selected from the group consisting of dibenzoyl peroxide, dilauroyl peroxide and azoisobutyrodinitrile.
4. Process according to claim 1 , wherein in step b) a wire is used which is preheated to a temperature in the region of the decomposition temperature of the thermally decomposing radical initiator.
5. Process according to claim 1 , wherein the injection moulding device is made of polytetrafluoroethylene or another inert plastic.