Polymer sliding material, artificial joint member, medical appliance, and manufacturing method therefor
View Patent ↗Disclosed is a sliding member with excellent durability and capable of maintaining wear resistance over a long period of time. Further disclosed is an artificial joint member for which the film thickness of the polymer base material is reduced. Further disclosed is an artificial joint which is capable of demonstrating high lubricity, biocompatibility, and resistance to dislocation after introduction into the body. Further disclosed are a medical appliance material and a medical appliance which demonstrate excellent biocompatibility. The sliding material or the medical appliance material is formed by a polymer layer or a biocompatible material layer (B) being provided by coating at least a portion of the surface of a polymer base material (A), the surface of which has a ketone group, and the polymer layer or biocompatible layer (B) is characterized by being formed by surface graft polymerization, wherein the polymer base material (A) is immersed in a reaction system which contains a monomer (C), the polymer base material (A) is exposed to light, and polymerization of the monomer is initiated from the surface of the polymer base material (A). Using the sliding material or medical appliance material, an artificial joint member, an artificial joint, a medical appliance material, and a medical appliance are manufactured.
1. A polymer sliding material comprising a polymer substrate (A) having ketone groups on the surface thereof and a coating layer (B) which coats at least a portion of the surface of the polymer substrate (A), wherein the coating layer (B) is formed by a surface graft polymerization comprising immersing the polymer substrate (A) in a reaction system containing a monomer (C), irradiating the polymer substrate (A) with light which is an ultraviolet ray or a visible ray, thereby polymerizing the monomer from the surface of the substrate.
2. The polymer sliding material according to claim 1 , wherein the coating layer (B) is formed through the graft polymerization without including a polymerization initiator in the surface and inside of the polymer substrate (A) and the reaction system containing the monomer (C).
3. The polymer sliding material according to claim 1 , wherein the polymer substrate (A) is the polymer substrate having an aromatic ketone.
4. The polymer sliding material according to claim 1 , wherein the polymer substrate (A) is a polymer selected from the group consisting of polyether ketone (PEK), polyetherether ketone (PEEK), polyether ketone ketone (PEKK), Polyetheretherketone ketone (PEEKK), polyether ketone ether ketone ketone (PEKEKK) and poly aryl ether ketone (PAEK), a composited polymer wherein at least two kinds of polymers from the above group are composited, and a fiber-reinforced polymer formed by a polymer selected from the above polymer and the composited polymer.
5. The polymer sliding material according to claim 1 , wherein the monomer (C) is selected from (meth)acrylate compounds.
6. The polymer sliding material according to claim 1 , wherein the monomer (C) contains a compound having a phosphoryl choline group.
7. The polymer sliding material according to claim 6 , wherein the compound having the phosphoryl choline group is 2-methacryloyloxyethyl phosphorylcholine (MPC).
8. The polymer sliding material according to claim 1 , wherein the coating layer (B) has a thickness of 10 to 200 nm.
9. The polymer sliding material according to claim 1 , wherein the surface of the sliding material shows a static water-contact angle of not more than 20° using a sessile drop method under the conditions in which the contact angle was measured after 60 seconds.
10. The polymer sliding material according to claim 1 , wherein each concentration of a phosphorus atom and a nitrogen atom on the surface of the sliding material measured by X-ray photoelectron spectroscopy is not less than 4 atom %.
11. An artificial joint component made of a polymer sliding material according to claim 1 , wherein a polymer substrate (A) constructs the proximal of the artificial joint component, and a coating layer (B) is formed on at least the sliding face of the artificial joint component.
12. The artificial joint component according to claim 11 , wherein the ball head to be combined has a thickness of not less than 32 mm and the polymer substrate has a thickness in the range from 3 to 6 mm.
13. An artificial joint, which is made of the artificial joint component of claim 11 .
14. A medical appliance material comprising a biocompatible material layer (B) covering at least a portion of the surface of the polymer substrate (A) having ketone groups on the surface thereof, wherein the biocompatible material layer (B) is formed by a surface graft polymerization comprising immersing the polymer substrate (A) in a reaction system containing a monomer (C), irradiating the polymer substrate (A) with light which is an ultraviolet ray or a visible ray, thereby polymerizing the monomer from the surface of the substrate.
15. The medical appliance material according to claim 14 , wherein the coating layer (B) is formed through the graft polymerization without including a polymerization initiator in the surface and inside of the polymer substrate (A) and the reaction system containing the monomer (C).
16. The medical appliance material according to claim 14 , wherein the polymer substrate (A) is the polymer substrate having an aromatic ketone.
17. The medical appliance material according to claim 14 , wherein the polymer substrate (A) is a polymer selected from the group consisting of polyether ketone (PEK), polyetherether ketone (PEEK), polyether ketone ketone (PEKK), Polyetheretherketone ketone (PEEKK), polyether ketone ether ketone ketone (PEKEKK) and poly aryl ether ketone (PAEK), a composited polymer wherein at least two kinds of polymers from the above group are composited, and a fiber-reinforced polymer formed by a polymer selected from the above polymer and the composited polymer.
18. The medical appliance material according to claim 14 , wherein the monomer (C) is selected from (meth)acrylate compounds.
19. The medical appliance material according to claim 14 , wherein the monomer (C) contains a compound having a phosphoryl choline group.
20. The medical appliance material according to claim 19 , wherein the compound having the phosphoryl choline group is 2-methacryloyloxyethyl phosphorylcholine (MPC).
21. The medical appliance material according to claim 14 , wherein the biocompatible material layer (B) has a thickness of 10 to 200 nm.
22. The medical appliance material according to claim 14 , wherein the surface of the biocompatible material layer (B) shows a static water-contact angle of not more than 20° using a sessile drop method under the conditions in which the contact angle was measured after 60 seconds.
23. The medical appliance material according to claim 14 , wherein each concentration of a phosphorus atom and a nitrogen atom on the surface of the biocompatible material layer (B) measured by X-ray photoelectron spectroscopy is not less than 4 atom %.
24. The medical appliance material according to claim 14 , wherein the adsorption of protein (albumin or fibrinogen) of the surface of the biocompatible material layer (B) obtained through the micro BCA method is not more than 0.1 microgram/cm 2 .
25. A medical appliance made of the medical appliance material according to claim 14 .
26. The medical appliance according to claim 25 selected from the group consisting of an artificial kidney, an artificial lung, an artificial trachea, a blood pump for an (auxiliary) artificial heart, an artificial valve, an artificial blood vessel, a catheter, a cardiac pacemaker, dental implant, an artificial tooth, an artificial bone, an artificial tendon, an artificial knuckle and a bone securing plate, a bone screw and so on.
27. A method of producing a medical appliance material comprising a polymer substrate (A) and a coating layer (B) which coats at least a portion of the surface of the polymer substrate (A), the method comprising immersing a polymer substrate (A) in a reaction system containing a monomer (C) for forming a biocompatible material layer (B), irradiating the polymer substrate (A) with light which is an ultraviolet ray or a visible ray, thereby initiating the polymerization of the monomer from the surface of the polymer substrate (A), wherein the polymer substrate (A) is a polymer having ketone groups on the surface thereof, and the reaction system containing the monomer (C) as well as the surface and the inside of the polymer substrate (A) includes no polymerization initiator.
28. The polymer sliding material according to claim 1 , wherein the light has a wavelength in a range from 200 nm to 450 nm.
29. The medical appliance material according to claim 14 , wherein the light has a wavelength in a range from 200 nm to 450 nm.
30. The method according to claim 27 , wherein the light has a wavelength in a range from 200 nm to 450 nm.