IP Library › Granted Patent US 8,772,243
Granted Patent B2
US 8,772,243 · App. 13/058,113 · Granted Jul 8, 2014

Methods for predicting the response to anti-cancer treatment with an agonist of TLR7 or an agonist of TLR8

Inventors: Julien Cherfils (Paris, FR); Herve Fridman (Paris, FR); Isabelle Cremer (Paris, FR)
Assignee: Inserm (Institut National de la Sante et de la Recherche Medicale)
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Quick Facts
Patent No.
US 8,772,243
App. No.
13/058,113
Granted
Jul 8, 2014
Kind
B2
Abstract

The present invention relates to methods for predicting the response to treatment with an agonist of TLR7, or an agonist of TLR8 or an anti-cancer agent for treating cancer, in particular non-small cell lung cancer comprising the step of detecting the expression of TLR7 or TLR8 in cancer cells of said patient.

Claims (6)

1. A method for treating a cancer patient who does not express TLR7 in cancer cells comprising

determining whether said cancer patient expresses TLR7 in cancer cells; and

administering a therapeutically effective amount of an agonist of TLR7 if said cancer patient does not express TLR7 in cancer cells.

2. The method of claim 1 wherein said agonist is used in combination with an anti-cancer agent.

3. The method of claim 1 , wherein said cancer is selected from the group consisting of lung cancer, breast cancer, colorectal cancer, renal carcinoma, prostate cancer, melanoma, and lymphoma.

4. The method of claim 1 , wherein said cancer is a solid cancer.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 27, 2011
From: CHERFILS, JULIEN; FRIDMAN, HERVE; CREMER, ISABELLE
To: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
Reel/Frame 026187/0047 →
Priority Claims (1)
EP 08305490 · Aug 20, 2008 · regional
Continuity (1)
Related Publication 20110195923A1 · Aug 11, 2011