Fumigillol type compounds and methods of making and using same
The disclosure provides a fumagillol type compound and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of using, e.g. in the treatment of obesity are provided.
1. A method of treating and/or controlling obesity, comprising administering to a patient in need thereof an effective amount of the compound represented by
or pharmaceutically acceptable salts or stereoisomers thereof.
2. A method of inducing weight loss in a patient in need thereof, comprising administering to said patient an effective amount of the compound represented by
or pharmaceutically acceptable salts or stereoisomers thereof.
3. The method of claim 1 , wherein the patient is a human.
4. The method of claim 1 , wherein the patient has a body mass index greater than or equal to about 25 kg/m 2 before the administration.
5. The method of claim 1 , wherein the compound is administered orally, intravenously, or subcutaneously.