Production and use of antitumoral cyclodepsipeptides
A compound having the general structure R 1 , R 2 , R 3 and R 4 being selected from the group consisting of a hydrogen atom (H) and a C 1 -C 20 alkyl, and R 5 being a phenyl radical.
1. A compound having the general structure
R 1 , R 2 , R 3 and R 4 being selected from the group consisting of a hydrogen atom (H) and a C 1 -C 20 alkyl,
and
R 5 being a phenyl radical.
2. The compound according to claim 1 , characterized in that at least one of R 1 , R 2 , R 3 and R 4 is a C 1 -C 20 alkyl having a substituent selected from the group consisting of an acyl radical, a formyl, acetyl, trichloroacetyl, fumaryl, maleyl, succinyl, or benzoyl group, a halogen radical, an aminoalkyl group, a hydroxyl group, an ether group or a carboxyl group.
3. The compound according to claim 1 having the following formula
including its diastereomeres.
4. The compound according to claim 1 having the following formula
including its diastereomeres.
5. A method for producing a compound having the general structure
R 1 , R 2 , R 3 and R 4 being selected from the group consisting of a hydrogen atom (H) and a C 1 -C 20
alkyl,
and
R 5 being a phenyl radical
characterized by the following steps:
a. cultivating a fungus of the species Scopulariopsis and
b. isolating the compound from the culture medium and/or the fungus.
6. The method according to claim 5 , characterized in that the fungus is Scopulariopsis brevicaulis.
7. A method of treating pancreatic or intestinal cancer by administering a substance having the general structure
R 1 , R 2 , R 3 and R 4 being selected from the group consisting of a hydrogen atom (H) and a C 1 -C 20 alkyl,
and
R 5 being a phenyl radical
as an antitumor agent.
8. The method of claim 7 wherein the substance is administered for the treatment of pancreatic cancer.
9. The compound according to claim 1 , characterized in that R 5 is a phenyl radical having a substituent selected from the group consisting of an acyl radical, a formyl, acetyl, trichloroacetyl, fumaryl, maleyl, succinyl, or benzoyl group, a halogen radical, an aminoalkyl group, a hydroxyl group, an ether group or a carboxyl group.