Method for killing IL-1 alpha expressing cells
Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL-1α and (ii) a constant region that is effective at both activating the complement system though C1q binding and binding to several different Fc receptors.
1. A method of killing a human cell expressing human interleukin-1alpha (IL-1α), the method comprising the step of contacting the cell with a purified human IgG1 monoclonal antibody (mAb) that specifically binds to human IL-1α, wherein the mAb comprises a heavy chain comprising the amino acid sequence of SEQ ID NO: 9 and a light chain comprising the amino acid sequence of SEQ ID NO: 11, and is conjugated to a cytotoxin.
2. The method of claim 1 , wherein the human cell is a cancer cell.