Articles incorporating absorbent polymer and ceragenin compound
An absorbent article includes an absorbent polymer and a ceragenin compound. The ceragenin compound has a sterol group and a plurality of cationic groups that mimic naturally occurring antimicrobial peptides. The ceragenin compound is associated with the absorbent polymer such that upon absorption of a fluid, the ceragenin compound is incorporated or maintained in the absorbent article.
1. An absorbent article, comprising:
a support structure; and
an absorbent polymer and a ceragenin compound associated with one another and supported on the support structure, the ceragenin compound including a sterol group and a plurality of cationic groups attached thereto;
wherein the ceragenin compound and absorbent polymer are a dry blended mixture or the ceragenin compound is provided at a pH between 2 and 6; and
wherein the ceragenin compound includes hydrolysable linkages between the sterol group and at least a portion of the cationic groups such that the ceragenin compound can degrade by hydrolysis in water.
2. The absorbent article of claim 1 , wherein the ceragenin compound is non-covalently attached to the absorbent polymer so as to associate the ceragenin compound with the absorbent polymer but allow the ceragenin compound to be released from the polymer in the presence of a microbe.
3. The absorbent article of claim 1 , wherein the ceragenin compound and the absorbent polymer are a dry blended mixture.
4. The absorbent article of claim 1 wherein the ceragenin compound is associated with the absorbent polymer such that upon exposure to an aqueous environment, the ceragenin compound elutes from the absorbent polymer in sufficient amount to provide an antimicrobial effect.
5. The absorbent article of claim 1 , wherein the support structure includes at least one sheet of a material.
6. The absorbent article of claim 5 , wherein the at least one sheet of material includes a nonwoven fabric, wherein the ceragenin compound is in or on the surface of the nonwoven fabric.
7. The absorbent article of claim 1 , further comprising material comprising cellulosic fibers.
8. The absorbent article of claim 1 , wherein the ceragenin is water hydrolysable ceragenin selected from the group consisting of CSA-32, CSA-33, CSA-34, CSA-35, CSA-41, CSA-42, CSA-43, CSA-44, CSA-45, CSA-47, CSA-49, CSA-50, CSA-51, CSA-52, CSA-56, CSA-141, CSA-142, and combinations thereof.
9. The absorbent article of claim 1 , further comprising an acidic material covalently or non-covalently associated with the absorbent polymer.
10. The absorbent article of claim 1 wherein the absorbent polymer comprises a polyacrylate-based superabsorbent polymer, with carboxylic acid groups (R—COOH) and carboxylate salts (R—COO-M+), and a mole ratio of carboxylic acid groups to carboxylate salts that is greater than 1:1.
11. The absorbent article of claim 1 wherein the amount of ceragenin compound associated with the support structure is sufficient to provide at least a minimum inhibitory concentration (MIC) for the ceragenin compound at or near an article-contacting body surface of the article.
12. The absorbent article of claim 11 wherein the type and concentration of the ceragenin compound is selected to provide an MIC sufficient to inhibit the growth of Staphylococcus aureus type MRSA or VRSA.
13. The absorbent article of claim 1 wherein the ceragenin compound is covalently bonded on a surface of the absorbent article.
14. The absorbent article of claim 1 , wherein the absorbent article is a disposable diaper, a feminine hygiene product, a sanitary napkin, a panty liner, a tampon, a product for adult incontinence, a personal care wipe, or a household wipe.
15. The absorbent article of claim 1 , wherein the article is a diaper and the support structure includes an outer shell, an absorbent pad, and an inner layer, wherein the absorbent pad includes absorbent polymer and the inner layer includes a material that wicks moisture toward the absorbent pad.
16. The absorbent article of claim 15 , wherein the ceragenin compound is disposed on an upper surface of the inner layer opposite the absorbent pad and/or within or on the absorbent pad.
17. The absorbent article of claim 1 , wherein the article is a bandage, the support structure comprising a flexible strip and the absorbent polymer disposed on the flexible strip, the flexible strip further comprising an adhesive that attaches the bandage to skin.
18. A packaged food comprising, a food material and an absorbent as in claim 1 .
19. A packaged food as in claim 18 , wherein the food material is a fruit, a vegetable, a dairy, a pork, a fish, a poultry, or a beef product or a combination thereof.