Cavity induced allosteric modification of intermolecular interactions and methods of identifying compounds that effect the same
View Patent ↗Method of identifying compounds that modulate intermolecular interactions between a target protein and a modifier are disclosed. Pharmaceutical composition comprising compounds that inhibit intermolecular interactions between a target protein and a modifier are disclosed. Methods of treating individual suffering from inflammatory conditions, undesirable immune responses, immunological conditions and bacterial infections are disclosed.
1. A method of inhibiting CD4-mediated signaling in a subject comprising administering to said subject an effective amount of a compound of Formula (IV), (V), or (VI),
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein said compound is a compound of formula (IV) or a pharmaceutically acceptable salt thereof.
3. The method of claim 1 , wherein said compound is a compound of formula (V) or a pharmaceutically acceptable salt thereof.
4. The method of claim 1 , wherein said compound is a compound of formula (VI) or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition comprising a compound having the
or a pharmaceutically acceptable salt thereof, and a pharmaceutical acceptable carrier or diluent.