Granted Patent
B2
US 8,796,266 · App. 13/905,515 · Granted Aug 5, 2014
Cyclothiocarbamate derivatives as progesterone receptor modulators
Inventors:
Puwen Zhang (Audubon, PA); Andrew Fensome (Stow, MA); Eugene A. Terefenko (Center Valley, PA); Lin Zhi (La Jolla, CA); Todd K. Jones (San Diego, CA); James P. Edwards (San Diego, CA); Christopher M. Tegley (Thousand Oaks, CA); Jay E. Wrobel (Lawrenceville, NJ); Mark A. Collins (Collegeville, PA)
Assignee:
Wyeth LLC
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Abstract
Methods of using compounds which are progesterone receptor agonists for contraception and the treatment of progesterone-related maladies alone or in combination with an estrogen receptor agonist or progesterone receptor antagonist are provided. These compounds have the structure: wherein R 1 , R 2 , R 3 , R 4 , R 5 , and Q 1 are defined herein.
Claims (1)
1. A method of treating endometriosis, said method comprising delivering 5-(4,4-Dimethyl-2-thioxo-1,4-dihydro-2H-3,1-benzoxazin-6-yl)-1-methyl-1H-pyrrole-2-carbonitrile or a pharmaceutically acceptable salt thereof to a female patient.
Assignments (6)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 15, 2014
From: ZHANG, PUWEN; FENSOME, ANDREW; TEREFENKO, EUGENE A.; WROBEL, JAY E.; COLLINS, MARK A.
To: AMERICAN HOME PRODUCTS CORPORATION
Reel/Frame 032899/0756 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 15, 2014
From: EDWARDS, JAMES P.; JONES, TODD K.; TEGLEY, CHRISTOPHER M.; ZHI, LIN
To: LIGAND PHARMACEUTICALS INC.
Reel/Frame 032899/0828 →
MERGER
Recorded May 15, 2014
From: AMERICAN HOME PRODUCTS CORPORATION
To: WYETH
Reel/Frame 032899/0933 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 15, 2014
From: LIGAND PHARMACEUTICALS INCORPORATED
To: WYETH
Reel/Frame 032899/0944 →