IP Library › Granted Patent US 8,802,646
Granted Patent B2
US 8,802,646 · App. 13/605,206 · Granted Aug 12, 2014

Method for selectively inhibiting the activity of ACAT1 in the treatment of alzheimer's disease

Inventors: Ta-Yuan Chang (Etna, NH); Catherine C. Y. Chang (Etna, NH); Elena Bryleva (Lebanon, NH); Stephanie Murphy (West Lebanon, NH); Maximillian A. Rogers (White River Junction, VT)
Assignee: Trustees of Dartmouth College
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Quick Facts
Patent No.
US 8,802,646
App. No.
13/605,206
Granted
Aug 12, 2014
Kind
B2
Abstract

The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by selectively inhibiting the activity of Acyl-CoA:Cholesterol Acyltransferase 1, but not Acyl-CoA:Cholesterol Acyltransferase 2.

Claims (2)

1. A method for treating Alzheimer's Disease comprising administering to a subject in need of treatment an effective amount of an siRNA or microRNA that inhibits the expression of Acyl-CoA:Cholesterol Acyltransferase 1 thereby treating the subject's Alzheimer's Disease, wherein the siRNA or microRNA comprises SEQ ID NO:37, 38, 39, 40, 43, or 44 and said siRNA or microRNA is administered via a liposome or nanoparticle.

2. The method of claim 1 , wherein the agent is selectively delivered to the brain of the subject.

Assignments (3)
CONFIRMATORY LICENSE Recorded Jan 14, 2019
From: DARTMOUTH COLLEGE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 048069/0388 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 2, 2014
From: BRYLEVA, ELENA; MURPHY, STEPHANIE; ROGERS, MAXIMILLIAN A.
To: TRUSTEES OF DARTMOUTH COLLEGE
Reel/Frame 032808/0359 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 13, 2013
From: CHANG, TA-YUAN; CHANG, CATHERINE C.Y.
To: TRUSTEES OF DARTMOUTH COLLEGE
Reel/Frame 030402/0354 →
Continuity (4)
Continuation In Part 13072915 · Mar 28, 2011
Continuation In Part PCTUS2009056601 · Sep 11, 2009
Provisional Application 61103658 · Oct 8, 2008
Related Publication 20130017252A1 · Jan 17, 2013