Controlled release particles and method for producing the same
Controlled release particles are obtained by dissolving a hydrophobic antibiotic compound in a hydrophobic polymerizable vinyl monomer without the presence of a solvent, thereby preparing a hydrophobic solution, the hydrophobic antibiotic compound having a melting point of 100° C. or less, a polar term δ p,compound of 2 to 8 [(J/cm 3 ) 1/2 ] of a solubility parameter (δ) and a hydrogen bonding term δ h,compound of 5.5 to 9.5 [(J/cm 3 ) 1/2 ] of the solubility parameter (δ), the solubility parameter (δ) defined by Hansen and calculated by van Klevelen and Hoftyzer method; dispersing the hydrophobic solution in water; and polymerizing the polymerizable vinyl monomer in the presence of an oil-soluble initiator by radical polymerization, thereby producing a polymer having a polar term δ p,polymer of 5 to 7 [(J/cm 3 ) 1/2 ] and a hydrogen bonding term δ h,polymer of 8 to 10 [(J/cm 3 ) 1/2 ] of the solubility parameter (δ).
1. Controlled release particles obtained by
dissolving a hydrophobic antibiotic compound in a hydrophobic polymerizable vinyl monomer without the presence of a solvent, thereby preparing a hydrophobic solution,
the hydrophobic antibiotic compound having a melting point of 100° C. or less, a polar term δ p,compound of 2 to 8 [(J/cm 3 ) 1/2 ] of a solubility parameter (δ), and a hydrogen bonding term δ h,compound of 5.5 to 9.5 [(J/cm 3 ) 1/2 ] of the solubility parameter (δ), the solubility parameter (δ) being defined by Hansen and calculated by van Krevelen and Hoftyzer method;
dispersing the hydrophobic solution in water; and
polymerizing the polymerizable vinyl monomer in the presence of an oil-soluble initiator by radical polymerization, thereby producing a polymer having a polar term δ p,polymer of 5 to 7 [(J/cm 3 ) 1/2 ] of the solubility parameter (δ) and a hydrogen bonding term δ h,polymer of 8 to 10 [(J/cm 3 ) 1/2 ] of the solubility parameter (δ),
the controlled release particles having a homogeneous phase including the polymer and the antibiotic compound.
2. The controlled release particles according to claim 1 , wherein the value of Δδ p obtained by deducting the polar term δ p,compound of the antibiotic compound from the polar term δ p,polymer of the polymer is −1.1 to 2.7 [(J/cm 3 ) 1/2 ], and
the value of Δδ h obtained by deducting the hydrogen bonding term δ h,compound of the antibiotic compound from the hydrogen bonding term δ h,polymer of the polymer is 0 to 4.2 [(J/cm 3 ) 1/2 ].
3. The controlled release particles according to claim 1 , wherein the mixing ratio of the antibiotic compound relative to the polymerizable vinyl monomer is 0.11 to 1.5 on a weight basis.