Nutritional supplements
View Patent ↗A process for improving the health of a subject, the process comprising orally administering a composition comprising hydroxytyrosol to the subject to provide the subject with a daily dose of about 0.1 to about 750 μg hydroxytyrosol per kg of body weight, and a dietary supplement in dosage unit form for oral administration, the dosage unit form comprising a composition containing about 1 microgram to about 50 milligrams hydroxytyrosol or an ester or salt thereof.
1. A dietary supplement in dosage unit form for oral administration, the dosage unit form comprising:
a composition containing about 0.5 to about 50 milligrams hydroxytyrosol or an ester or salt thereof, N-acetyl cysteine, glycine, L-taurine, L-proline, methylsulfonylmethane, niacinamide, and pyridoxine,
wherein the hydroxytyrosol or an ester or salt thereof comprises hydroxytyrosol and oleuropein,
wherein the weight ratio of N-acetyl cysteine to hydroxytyrosol is between 1:1 and 50:1,
wherein the weight ratio of glycine to hydroxytyrosol is between 1:1 and 50:1,
wherein the ratio of L-taurine to hydroxytyrosol is between 1:1 and 50:1, and
wherein the weight ratio of L-proline to hydroxytyrosol is between 1:1 and 20:1.
2. The dietary supplement of claim 1 , wherein the dosage unit form comprises 0.5 milligrams to 5 milligrams hydroxytyrosol or an ester or salt thereof.
3. The dietary supplement of claim 1 , wherein the dosage unit form comprises 1 to 25 milligrams hydroxytyrosol or an ester or salt thereof.
4. The dietary supplement of claim 1 wherein the dosage unit form comprises 1 to 20 milligrams hydroxytyrosol or an ester or salt thereof.
5. The dietary supplement of claim 1 wherein the dosage unit form comprises 1 to 15 milligrams hydroxytyrosol or an ester or salt thereof.
6. The dietary supplement of claim 1 wherein the dosage unit form comprises 1 to 10 milligrams hydroxytyrosol or an ester or salt thereof.
7. The dietary supplement of claim 1 wherein the dosage unit form comprises 2.5 to 7.5 milligrams hydroxytyrosol or an ester or salt thereof.
8. The dietary supplement of claim 1 wherein the weight ratio of N-acetyl cysteine to hydroxytyrosol is between 10:1 and 30:1, respectively.
9. The dietary supplement of claim 8 wherein the weight ratio of N-acetyl cysteine to hydroxytyrosol is between 20:1 and 25:1, respectively.
10. The dietary supplement of claim 1 wherein the weight ratio of glycine to hydroxytyrosol is between 30:1 and 40:1, respectively.
11. The dietary supplement of claim 10 wherein the weight ratio of glycine to hydroxytyrosol is about 35:1, respectively.
12. The dietary supplement of claim 1 wherein the ratio of L-taurine to hydroxytyrosol is between 20:1 and 50:1, respectively.
13. The dietary supplement of claim 12 wherein the weight ratio of L-taurine to hydroxytyrosol is between 30:1 and 40:1, respectively.
14. The dietary supplement of claim 1 wherein the weight ratio of L-proline to hydroxytyrosol is between 1:1 and 10:1, respectively.
15. The dietary supplement of claim 14 wherein the weight ratio of L-proline to hydroxytyrosol is between 1:1 and 5:1, respectively.
16. The dietary supplement of claim 1 wherein the weight ratio of methylsulfonylmethane to hydroxytyrosol is between 1:1 and 30:1, respectively.
17. The dietary supplement of claim 16 wherein the weight ratio of methylsulfonylmethane to hydroxytyrosol is between 10:1 and 20:1, respectively.
18. The dietary supplement of claim 1 wherein the weight ratio of niacinamide to hydroxytyrosol is between 1:1 and 10:1, respectively.
19. The dietary supplement of claim 18 wherein the weight ratio of niacinamide to hydroxytyrosol is between 1:1 and 2:1, respectively.
20. The dietary supplement of claim 1 wherein the weight ratio of pyridoxine to hydroxytyrosol is between 1:1 and 10:1, respectively.
21. The dietary supplement of claim 20 wherein the weight ratio of pyridoxine to hydroxytyrosol is between 1:1 and 2:1, respectively.
22. The dietary supplement of claim 1 wherein weight ratio N-acetyl cysteine to hydroxytyrosol is between 10:1 and 30:1, respectively, the weight ratio glycine to hydroxytyrosol is between 30:1 and 40:1, respectively, the weight ratio of L-taurine to hydroxytyrosol is between 20:1 and 50:1, respectively, the weight ratio of L-proline to hydroxytyrosol is between 1:1 and 10:1, respectively, the weight ratio of niacinamide to hydroxytyrosol is between 1:1 and 10:1, respectively, the weight ratio of pyridoxine to hydroxytyrosol is between 1:1 and 10:1, and the weight ratio of methylsulfonylmethane to hydroxytyrosol is between 1:1 and 30:1.
23. The dietary supplement of claim 1 wherein weight ratio N-acetyl cysteine to hydroxytyrosol is between 20:1 and 25:1, respectively, the weight ratio glycine to hydroxytyrosol is between 30:1 and 40:1, respectively, the weight ratio of L-taurine to hydroxytyrosol is between 30:1 and 40:1, respectively, the weight ratio of L-proline to hydroxytyrosol is between 1:1 and 5:1, respectively, the weight ratio of niacinamide to hydroxytyrosol is between 1:1 and 2:1, respectively, the weight ratio of pyridoxine to hydroxytyrosol is between 1:1 and 2:1, and the weight ratio of methylsulfonylmethane to hydroxytyrosol is between 10:1 and 20:1.
24. The dietary supplement of claim 1 wherein the dosage unit form provides about 250 to 4,000 TE of systemically bioavailable hydroxytyrosol.
25. The dietary supplement of claim 24 wherein weight ratio N-acetyl cysteine to hydroxytyrosol is between 20:1 and 25:1, respectively, the weight ratio glycine to hydroxytyrosol is between 30:1 and 40:1, respectively, the weight ratio of L-taurine to hydroxytyrosol is between 30:1 and 40:1, respectively, the weight ratio of L-proline to hydroxytyrosol is between 1:1 and 5:1, respectively, the weight ratio of niacinamide to hydroxytyrosol is between 1:1 and 2:1, respectively, the weight ratio of pyridoxine to hydroxytyrosol is between 1:1 and 2:1, and the weight ratio of methylsulfonylmethane to hydroxytyrosol is between 10:1 and 20:1.
26. The dietary supplement of claim 1 wherein the dosage unit form provides about 500 to 3,500 TE of systemically bioavailable hydroxytyrosol per day.
27. The dietary supplement of claim 26 wherein weight ratio N-acetyl cysteine to hydroxytyrosol is between 20:1 and 25:1, respectively, the weight ratio glycine to hydroxytyrosol is between 30:1 and 40:1, respectively, the weight ratio of L-taurine to hydroxytyrosol is between 30:1 and 40:1, respectively, the weight ratio of L-proline to hydroxytyrosol is between 1:1 and 5:1, respectively, the weight ratio of niacinamide to hydroxytyrosol is between 1:1 and 2:1, respectively, the weight ratio of pyridoxine to hydroxytyrosol is between 1:1 and 2:1, and the weight ratio of methylsulfonylmethane to hydroxytyrosol is between 10:1 and 20:1.