Neurologically based non-invasive blood glucose concentration system and method

1. A method for determining glucose concentration in the blood of a user, the method comprising the steps of:

collecting psychometric data for the user;

using a light source to bleach retinal pigments in the eye of the user;

after bleaching the retinal pigments, presenting a visual perceptual task on a display device to the user, the visual perception task based on the psychometric data;

sensing neurophysiological brain activity of the user while presenting the visual perception task on the display device; and

in a processor, correlating the sensed neurophysiological brain activity to the glucose concentration in the blood of the user.

2. The method of claim 1 , wherein the step of presenting a visual perceptual task comprises displaying, on the display device, a sequence of images to the user, the sequence of images including a specific target.

3. The method of claim 2 , further comprising displaying, on the display device, a plurality of sequences of images that each include the specific target.

4. The method of claim 3 , wherein:

the step of sensing neurophysiological brain activity of the user comprises sensing event-related potentials (ERPs); and

the method further comprises, in the processor:

measuring amplitude and latency of peaks in the neurophysiological brain activity while the plurality of sequences of images are displayed; and

correlating changes in the amplitude and latency to visual pigment regeneration rate.

5. The method of claim 1 , wherein the step of presenting a visual perceptual task comprises displaying, on the display device, an image to the user, the image oscillating at a predetermined frequency.

6. The method of claim 5 , wherein:

the step of sensing neurophysiological brain activity of the user comprises sensing steady state visual evoked response potentials (SSVEPs); and

the method further comprises, in the processor:

determining changes in amplitude of the SSVEPs at the predetermined frequency; and

correlating changes in the amplitude to visual pigment regeneration rate.

7. The method of claim 1 , further comprising:

establishing baseline neurophysiological brain activity for the user;

sensing one or more environmental parameters; and

using the baseline neurophysiological brain activity and the one or more sensed environmental parameters to correlate the sensed neurophysiological brain activity to the glucose concentration in the blood of the user.

8. The method of claim 1 , further comprising:

generating an alert to remind the user to check blood glucose concentration.

9. The method of claim 1 , further comprising:

generating feedback representative of the glucose concentration in the blood of the user.

10. A method for determining glucose concentration in the blood of a user, the method comprising the steps of:

using a light source, bleaching retinal pigments in the eye of the user to cause the eye to undergo retinal pigment regeneration;

displaying a plurality of sequences of images on a display device to the user, each sequence of images including a specific target; and

in a processor, measuring amplitude and latency of peaks in event-related potentials while the plurality of sequences of images are displayed;

correlating changes in the amplitude and latency to visual pigment regeneration rate; and

correlating the visual pigment regeneration rate to the glucose concentration in the blood of the user.

11. A non-invasive blood glucose concentration sensing system, comprising:

a neurophysiological brain activity sensor configured to sense event-related potentials (ERPs) of a user and supply signals representative thereof;

a display device responsive to display commands to render images;

a light source coupled to the processor and configured to selectively emit a bleaching light into an eye of the user to bleach retinal pigments in the eye; and

a processor coupled to the display device and the neurophysiological brain activity sensor and configured to:

control emission of the bleaching light from the light source,

after emission of the bleaching light from the light source, present a visual perceptual task to the user by commanding the display device to render a sequence of images to the user, the sequence of images including a specific target,

command the display device to render a plurality of sequences of images that each include the specific target,

measure amplitude and latency of peaks in the neurophysiological brain activity while the plurality of sequences of images are displayed,

correlate changes in the amplitude and latency to visual pigment regeneration rate, and

correlate the visual pigment regeneration rate to blood glucose concentration of the user.

12. The system of claim 11 , wherein the processor is further configured to generate an alert to remind the user to check blood glucose concentration.

13. The system of claim 11 , wherein the processor is further configured to generate feedback representative of the glucose concentration in the blood of the user.

14. A method for determining glucose concentration in the blood of a user, the method comprising the steps of:

using a light source, bleaching retinal pigments in the eye of the user to cause the eye to undergo retinal pigment regeneration;

displaying an image to the user on a display device, the image oscillating at a predetermined frequency;

sensing steady state visual evoked response potentials (SSVEPs) while the image is being displayed; and

in a processor, determining changes in amplitude of the SSVEPs at the predetermined frequency;

correlating changes in the amplitude to visual pigment regeneration rate; and

correlating the visual pigment regeneration rate to the glucose concentration in the blood of the user.

15. A non-invasive blood glucose concentration sensing system, comprising:

a neurophysiological brain activity sensor configured to sense steady state visual evoked response potentials (SSVEPs) of a user and supply signals representative thereof;

a display device responsive to display commands to render images;

a light source coupled to the processor and configured to selectively emit a bleaching light into an eye of the user to bleach retinal pigments in the eye; and

a processor coupled to the display device and the neurophysiological brain activity sensor and configured to:

control emission of the bleaching light from the light source,

after emission of the bleaching light from the light source, present a visual perceptual task to the user by commanding the display device to render an image oscillating at a predetermined frequency,

determine changes in amplitude of the SSVEPs at the predetermined frequency,

correlate changes in the amplitude to visual pigment regeneration rate, and

correlate the visual pigment regeneration rate to blood glucose concentration of the user.

16. The system of claim 15 , wherein the processor is further configured to generate an alert to remind the user to check blood glucose concentration.

17. The system of claim 15 , wherein the processor is further configured to generate feedback representative of the glucose concentration in the blood of the user.