IP Library Granted Patent US 8,815,233
Granted Patent B2
US 8,815,233 · App. 13/448,061 · Granted Aug 26, 2014

Method for treating pervasive development disorders

Inventor: Joan M. Fallon (Bronxville, NY)
Assignee: Curemark LLC
C12Q1/37G01N2333/976A61K38/2235Y10S435/803
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Quick Facts
Patent No.
US 8,815,233
App. No.
13/448,061
Granted
Aug 26, 2014
Kind
B2
Abstract

A method of utilizing the chymotrypsin level of an individual as a measure of the success of secretin, other neuropeptides, and peptides or digestive enzyme administration to such individuals, and in particular, as a prognosticative of potential secretin, other neuropeptides, peptides, and digestive enzyme administration for persons having ADD, ADHD, Autism and other PDD related disorders.

Claims (21)

1. A method of treating a pervasive development disorder (PDD), comprising:

administering a pharmaceutical composition comprising digestive enzymes to an individual having a PDD and a subnormal level of fecal chymotrypsin, wherein the digestive enzymes comprise amylase, protease and lipase, and wherein one or more symptoms of the PDD are ameliorated.

2. The method of claim 1 , wherein the PDD is selected from the group consisting of Autism, Asperger's, attention deficit disorder (ADD), and attention deficit hyperactive disorder (ADHD).

3. The method of claim 1 , wherein the individual is from 2 to 4 years of age.

4. The method of claim 1 , wherein the individual is from 1 to 6 years of age.

5. The method of claim 1 , wherein the individual is from 5 to 12 years of age.

6. The method of claim 1 , wherein the individual is from 7 to 12 years of age.

7. The method of claim 1 , wherein the individual is from 2 to 12 years of age.

8. The method of claim 1 , wherein the individual is from 1 to 12 years of age.

9. The method of claim 1 , wherein the pharmaceutical composition is administered from 3-6 times per day.

10. The method of claim 1 , wherein the pharmaceutical composition is administered 3 times per day.

11. The method of claim 1 , wherein a dose of the digestive enzymes comprises from 4,000-20,000 U.S.P. units of lipases.

12. The method of claim 1 , wherein a dose of the digestive enzymes comprises from 10,000-50,000 U.S.P. units of proteases.

13. The method of claim 1 , wherein a dose of the digestive enzymes comprises from 10,000-60,000 U.S.P. units of amylases.

14. The method of claim 1 , wherein a dose of the digestive enzymes comprises from 2,000-6,000 U.S.P. units of pancreatin.

15. The method of claim 1 , wherein the digestive enzymes are provided as pancreatin.

16. The method of claim 1 , wherein the individual's fecal chymotrypsin level is determined by using an enzymatic spectrophotometry method.

17. The method of claim 16 , wherein the enzymatic spectrophotometry method is performed at 30° C.

18. The method of claim 1 , wherein the individual's determined fecal chymotrypsin level is below 8.4 U/gm.

19. The method of claim 1 , wherein the individual's determined fecal chymotrypsin level is below 8.4 U/gm but above or equal to 4.2 U/gm.

20. The method of claim 1 , wherein the individual's determined fecal chymotrypsin level is below 4.2 U/gm.

Assignments (2)
CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY DATA PREVIOUSLY RECORDED AT REEL: 030469 FRAME: 0930. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Feb 9, 2017
From: FALLON, JOAN M.
To: CUREMARK, LLC
Reel/Frame 041671/0478 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 22, 2013
From: FALLON, JOAN M.
To: CUREMARK LLC
Reel/Frame 030469/0930 →
Continuity (6)
Continuation 12487864 · Jun 19, 2009
Continuation 12283090 · Sep 8, 2008
Continuation 10681018 · Oct 8, 2003
Continuation 09707395 · Nov 7, 2000
Continuation 09466559 · Dec 17, 1999
Related Publication 20120207740A1 · Aug 16, 2012