Lung aerosol collection device
A device for collecting material from lung aerosols. The device functions by collecting aerosols from the lower airway separated from material in the by collecting air from the upper airway in a chamber that when full causes the remaining exhaled aerosols from the lungs to be captured by a filter. The filter collects sample of material from the separated lung aerosols.
1. A process of sampling aerosolized lung material comprising: providing a collection device comprising a conduit having a first open end and a second end, said conduit connected to a filter; separating upper airway fluid from aerosolized lung material lower airway fluid by inserting said first open end of said collection device a distance posterior to at least one tooth of a subject, wherein the first open end is located in the oral cavity of the subject, and sampling the aerosolized lung material by passing the aerosolized lung material through said conduit, while the first open end is located in the oral cavity of the subject, said aerosolized lung material lower airway fluid traversing said filter to trap aerosolized material in said filter.
2. The process of claim 1 wherein said distance is 5 millimeters or more posterior to at least one tooth of the subject.
3. The process of claim 1 wherein said distance is between 5 and 80 millimeters posterior to at least one tooth of the subject.
4. The process of claim 1 wherein said distance is from 20 to 30 millimeters posterior to at least one tooth of the subject.
5. The process of claim 1 wherein said device further comprises an identifiable position on said conduit between said first open end and said second end, said position defining said distance during collection of aerosolized material from a lung.
6. The process of claim 1 wherein said device further comprises a shaft fluidly connected to said conduit;
at least a portion of said shaft between said conduit and said filter.
7. The process of claim 1 wherein said device further comprises a chamber fluidly connected to said conduit at said second end.
8. A process of discriminatorily sampling lower airway material comprising: providing a collection device comprising a conduit having a first open end and a second end, said conduit connected to a sampling apparatus; separating upper airway fluid from lower airway aerosolized material by inserting said first open end of said collection device a distance posterior to at least one tooth of a subject, wherein the first open end is located in the oral cavity of the subject; and contacting said lower airway aerosolized material with said sampling apparatus to sample the aerosolized lung material by passing the aerosolized lung material through said conduit, while the first open end is located in the oral cavity of the subject.
9. The process of claim 8 wherein said sampling apparatus is a filter or a detector.
10. The process of claim 8 wherein said distance is greater than 5 millimeters posterior to at least one tooth of the subject.
11. The process of claim 8 wherein said distance is between 5 and 80 millimeters posterior to at least one tooth of the subject.
12. The process of claim 8 wherein said distance is between 20 and 30 millimeters posterior to at least one tooth of the subject.
13. The process of claim 8 wherein said material is an analyte.
14. The process of claim 13 further comprising:
detecting the presence or absence of said analyte interacting with said sampling apparatus.