IP Library Granted Patent US 8,822,535
Granted Patent B2
US 8,822,535 · App. 11/408,734 · Granted Sep 2, 2014

Methods, compositions and articles of manufacture for enhancing survivability of cells, tissues, organs, and organisms

Inventors: Mark B. Roth (Seattle, WA); Mike Morrison (Seattle, WA); Eric Blackstone (Seattle, WA); Dana Miller (Seattle, WA)
Assignee: Fred Hutchinson Cancer Research Center
A61K33/04Y10S514/921
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Quick Facts
Patent No.
US 8,822,535
App. No.
11/408,734
Granted
Sep 2, 2014
Kind
B2
Abstract

The present invention concerns the use of oxygen antagonists and other active compounds for inducing stasis or pre-stasis in cells, tissues, and/or organs in vivo or in an organism overall, in addition to enhancing their survivability. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability and for achieving stasis or pre-stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, there are also therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the active compounds described.

Claims (3)

1. A method for treating hemorrhagic shock comprising administering to a subject in need thereof an effective amount of a H 2 S intravenously or by inhalation.

2. The method of claim 1 , wherein the effective amount of the H 2 S is administered intravenously.

3. The method of claim 1 , wherein the effective amount of the H 2 S is administered by inhalation.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 4, 2010
From: ROTH, MARK B.; MORRISON, MIKE; BLACKSTONE, ERIC; MILLER, DANA
To: FRED HUTCHINSON CANCER RESEARCH CENTER
Reel/Frame 025089/0126 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 18, 2006
From: ROTH, MARK B; MORRISON, MIKE; BLACKSTONE, ERIC; MILLER, DANA
To: FRED HUCHINSON CANCER RESEARCH CENTER
Reel/Frame 018266/0125 →
Continuity (6)
Provisional Application 60673037 · Apr 20, 2005
Provisional Application 60673295 · Apr 20, 2005
Provisional Application 60713073 · Aug 31, 2005
Provisional Application 60731549 · Oct 28, 2005
Provisional Application 60762462 · Jan 26, 2006
Related Publication 20070078113A1 · Apr 5, 2007