IP Library › Granted Patent US 8,828,384
Granted Patent B2
US 8,828,384 · App. 13/927,352 · Granted Sep 9, 2014

Compounds

Inventors: Stephanie Jane Clegg (Stevenage, GB); Eric Dobrzynski (King of Prussia, PA); Jonathan H. Ellis (Stevenage, GB); Volker Germaschewski (Stevenage, GB); Alexis Pual Godillot (King of Prussia, PA); Zdenka Ludmila Jonak (King of Prussia, PA); Alan P. Lewis (Stevenage, GB); John R. White (King of Prussia, PA)
Assignee: GlaxoSmithKline LLC
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Quick Facts
Patent No.
US 8,828,384
App. No.
13/927,352
Granted
Sep 9, 2014
Kind
B2
Abstract

The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.

Claims (4)

1. A method of treating inflammatory bowel disease (IBD) or psoriasis in a patient comprising administering to the patient an effective treatment amount of an antibody comprising heavy and light chain variable regions which comprise the CDR amino acid sequences of SEQ ID NOs: 13, 14, and 15; and SEQ ID NOs: 16, 17, and 18, respectively.

2. The method of treating IBD or psoriasis of claim 1 in which the antibody has heavy and light chains comprising the amino acid sequences of SEQ ID NO:46, and SEQ ID NO: 48, 60, 62, or 64, respectively.

3. The method of treating IBD or psoriasis of claim 1 in which the antibody has heavy and light chains comprising amino acid sequences of SEQ ID NO:46 and SEQ ID NO: 62, respectively.

4. The method of treating IBD or psoriasis of claim 1 in which the antibody is Humanized.

Assignments (2)
CHANGE OF NAME Recorded Aug 15, 2013
From: SMITHKLINE BEECHAM CORPORATION
To: GLAXOSMITHKLINE LLC
Reel/Frame 031017/0562 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 26, 2013
From: CLEGG, STEPHANIE JANE; DOBRZYNSKI, ERIC; ELLIS, JONATHAN H.; GERMASCHEWSKI, VOLKER; GODILLOT, ALEXIS PAUL; JONAK, ZDENKA LUDMILA; LEWIS, ALAN P.; WHITE, JOHN R.
To: SMITHKLINE BEECHAM CORPORATION
Reel/Frame 030688/0933 →
Continuity (3)
Division 12596262
Provisional Application 61044132 · Apr 11, 2008
Related Publication 20140010807A1 · Jan 9, 2014