IP Library › Granted Patent US 8,828,395
Granted Patent B2
US 8,828,395 · App. 13/162,559 · Granted Sep 9, 2014

Antibodies that bind tyrosyl-tRNA synthetases

Inventors: Jeffry Dean Watkins (Encinitas, CA); Alain P. Vasserot (Carlsbad, CA); Rajesh Belani (San Diego, CA); Leslie Ann Greene (San Diego, CA); Ryan Andrew Adams (San Diego, CA)
Assignee: aTyr Pharma, Inc.
C07K16/40C07K2317/20C07K2317/33A61K39/39533
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Quick Facts
Patent No.
US 8,828,395
App. No.
13/162,559
Granted
Sep 9, 2014
Kind
B2
Abstract

Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.

Claims (5)

1. An isolated antibody that exhibits binding specificity for an isolated tyrosyl-tRNA synthetase (YRS) polypeptide of SEQ ID NO:1, 2 or 3, wherein affinity of the antibody for the YRS polypeptide of SEQ ID NO:2 or 3 is at least about 1.5× stronger than its affinity for the YRS polypeptide of SEQ ID NO:1.

2. The antibody of claim 1 , wherein affinity of the antibody for the YRS polypeptide of SEQ ID NO:2 or 3 is at least about 10× stronger than its affinity for the YRS polypeptide of SEQ ID NO:1.

3. The antibody of claim 1 , wherein the antibody is a monoclonal antibody.

4. The antibody of claim 1 , wherein the antibody is a polyclonal antibody.

5. The antibody of claim 4 , wherein the antibody is a rabbit antibody.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 22, 2011
From: WATKINS, JEFFRY DEAN; VASSEROT, ALAIN P.; BELANI, RAJESH; GREENE, LESLIE ANN; ADAMS, RYAN ANDREW
To: ATYR PHARMA, INC.
Reel/Frame 027269/0982 →
Continuity (6)
Continuation In Part 12965655 · Dec 10, 2010
Provisional Application 61285907 · Dec 11, 2009
Provisional Application 61304283 · Feb 12, 2010
Provisional Application 61334127 · May 12, 2010
Provisional Application 61359767 · Jun 29, 2010
Related Publication 20120064082A1 · Mar 15, 2012