Treatment of pediatric tumors
View Patent ↗A subclass of camptothecin derivatives is disclosed to be useful for the preparation of a medicament for the treatment of pediatric tumors such as for examplerhabdomyosarcoma, primitive neuroectodermal tumors (PNET) and neuroblastoma.
1. Method of treating a mammal suffering from a pediatric tumor pathology selected from the group consisting of rhabdomyosarcoma, primitive neuroectodermal tumors (PNET) and neuroblastoma comprising administering a therapeutically effective amount of a compound of Formula I,
where R is hydrogen or methyl, or a pharmaceutical composition containing the same and pharmaceutically acceptable carriers and/or excipients.
2. The method according to claim 1 , wherein the pediatric tumors are head and neck carcinoma selected from the group consisting of rhabdomyosarcoma, primitive neuroectodermal tumors (PNET) and neuroblastoma.
3. The method of claim 1 , wherein the compound of Formula I is
7-(2-amino)ethoxyiminomethylcamptothecin or
7-(2-dimethylamino)ethoxyiminomethylcamptothecin.
4. The method of claim 1 , wherein the therapeutically effective amount is from 0.01 mg/kg to 100 mg/kg.
5. The method of claim 1 , wherein the therapeutically effective amount is from 0.05 mg/kg to 50 mg/kg.