Prevention and treatment of sarcopenia
The present invention provides a means for prevention and treatment of sarcopenia by administration of a substance that both reduces the sensibility of beta-adrenergic receptors and of 5-HT1a receptors. (S)-pindolol, (S)-propanol, tertalol, or bopindolol are preferred for this purpose.
1. A method of treating a patient exhibiting sarcopenia without cachexia, comprising administering to the patient in need thereof a therapeutically effective amount of S-pindolol.
2. The method of claim 1 , wherein the patient is aged 60 years or older.
3. The method of claim 1 wherein the therapeutically effective amount is administered as a single dose.
4. The method of claim 1 wherein the therapeutically effective amount is administered in divided doses.
5. The method of claim 1 , wherein a daily dose of 2.5 mg to 50 mg is administered.
6. The method of claim 5 wherein the daily dose is administered as a single dose.
7. The method of claim 5 , wherein the daily dose is administered in divided doses.
8. The method of claim 1 , wherein the S-pindolol is administered in a pharmaceutical formulation selected from the group consisting of tablets, capsules, liquid, oral solutions, oral suspensions, parenteral solutions, buccal melts, intravenous solutions, and topical application forms.