Polynucleotide nanomechanical device that acts as an artificial ribosome and translates DNA signals into polymer assembly instructions
A polynucleic acid nanomechanical device with a linear array of alternating PX-JX 2 devices and nucleic acid multi-crossover motifs that facilitate the assembly of a nucleic acid strand and functions as an artificial ribosome by translating a nucleic acid signal into an unrelated nucleic acid sequence.
1. A polynucleic acid polymer, comprising the general formula (I)
wherein:
A=a Group VI element selected from the group consisting of O, S, Se, and Te;
G, J, Q=a linker group selected from the group consisting of C 1 -C 18 branched and straight chain alkyl groups, C 6 -C 24 substituted and unsubstituted aromatic and heteroaromatic groups having from 1-3 hetero atoms (N,S,O) or halogen substitution, —O—, —S—, carbonyl, carboxyl, —SiR 2 —, and —OSiR 2 O—;
B=a nucleic acid base selected from the group consisting of U, T, A, G, C, and derivatives thereof, and can be the same or different;
E=a symmetric or asymmetric atom center selected from the group consisting of CR, N, NR+, phosphine, phosphine oxide, phosphate, phosphonate, phosphinate, phosphoramide, phosphonamide, and phosphinamide;
R=a terminal group selected from the group consisting of H, C 1 -C 18 branched and straight chain alkyl groups, C 6 -C 24 substituted and unsubstituted aromatic and heteroaromatic groups having from 1-3 hetero atoms (N,S,O) or halogen substitution; and
Pair XY=bonding sites such that X forms a covalent bond with Y by the techniques of organic synthesis.
2. The polymer of claim 1 , comprising formula (III)