Antimicrobial solutions and methods
Antimicrobial solutions and delivery systems for them use liquid antimicrobial solutions with: at least 80% of total weight of a carrier liquid comprising water, alcohol or a mixture of water and alcohol; at least 0.0001% by weight of the solution of I 2 ; at least 0.0001% by weight of CuSO 4 ; and sufficient acid in the solution top provide a pH of less than 7.0. A buffering system is also preferable in the solution, and the solution may be provided directly to wounds, burns or other skin damage as a liquid, as a spray or as a gel.
1. A method of treating a wound or burn on tissue comprising applying an antimicrobial composition to the wound or burn on tissue, the antimicrobial composition comprising: at least 80% of total weight of a carrier liquid comprising water, alcohol, aqueous gel or a mixture of water and alcohol, water and aqueous gel, alcohol and aqueous gel, or water and alcohol and aqueous gel; at least 0.001% by weight of the solution of I 2 ; and at least 0.005% by weight of CuSO 4 and sufficient acid in the solution to provide a pH of less than 6.9 wherein the acid comprises a sulfamic acid compound having the formula: NR 2 SO 3 H, wherein R is independently selected from the group consisting of hydrogen and electron-withdrawing groups.
2. A method of treating a wound or burn on tissue comprising applying an antimicrobial composition to the wound or burn on tissue, the antimicrobial composition comprising: at least 80% of total weight of a carrier liquid comprising water, alcohol, aqueous gel or a mixture of water and alcohol, water and aqueous gel, alcohol and aqueous gel, or water and alcohol and aqueous gel; at least 0.001% by weight of the solution of I 2 ; and sufficient acid in the solution to provide a pH of less than 6.9 wherein the acid comprises a sulfamic acid compound having the formula: NR 2 SO 3 H, wherein R is independently selected from the group consisting of hydrogen, halogen, cyano, C1-C6 alkyl, C1 to C6 substituted alkyl, perhalo alkyl, halosubstituted alkyl, and electron-withdrawing groups.
3. The method of claim 2 wherein at least one R is hydrogen.
4. The method of claim 2 wherein exactly one R is hydrogen.
5. A method of treating a wound on tissue comprising applying an antimicrobial composition comprising a solution to the wound on tissue, the solution comprising:
at least 80% of total weight of a carrier liquid comprising water, alcohol, or a mixture of water and alcohol; at least 0.001% by weight of the solution of I 2 and at least 0.005% by weight of CuSO 4 ; and sufficient acid in the solution to provide a pH of from 5.5 to 6.7, wherein the acid comprises a sulfamic acid compound having the formula: NR 2 SO 3 H, wherein R is independently selected from the group consisting of hydrogen, halogen, cyano, C1-C6 alkyl, C1 to C6 substituted alkyl, perhalo alkyl, halosubstituted alkyl, and electron-withdrawing groups.
6. The method of claim 1 wherein the solution is carried in a gel, ointment or cream.
7. The method of claim 2 wherein the solution is distributed within a gel.
8. The method of claim 6 wherein the acid is sufficient in an amount to provide a pH of from 5.5 to 6.7; and the solution further comprising an inorganic cation and I 2 and at least 0.005% by weight of CuSO 4 .
9. The method of claim 5 wherein the acid comprises sulfamic acid.
10. A method of treating a wound on tissue comprising applying an antimicrobial composition comprising a solution to the wound on tissue, the solution comprising: at least 80% of total weight of a carrier liquid comprising water, alcohol, or a mixture of water and alcohol; at least 0.001% by weight of the solution of I 2 ; and sufficient acid in the solution to provide a pH of less than 6.9 wherein the acid comprises sulfamic acid.
11. A method of treating a wound on tissue comprising applying an antimicrobial composition comprising a solution to the wound on tissue, the solution comprising: at least 80% of total weight of a carrier liquid comprising water, alcohol, or a mixture of water and alcohol; at least 0.001% by weight of the solution of I 2 ; and sufficient acid in the solution to provide a pH of from 5.5 TO 6.7 wherein the acid comprises a sulfamic acid compound having the formula: NR 2 SO 3 H, wherein R is independently selected from the group consisting of hydrogen, halogen, cyano, C1-C6 alkyl, C1 to C6 substituted alkyl, perhalo alkyl, halosubstituted alkyl, and electron-withdrawing groups.
12. The method of claim 11 wherein at least one R is hydrogen.
13. The method of claim 10 wherein the acid is sufficient in an amount to provide a pH of from 5.5 to 6.7; and the solution further comprising an inorganic cation and I 2 and at least 0.005% by weight of CuSO 4 .