IP Library › Granted Patent US 8,846,656
Granted Patent B2
US 8,846,656 · App. 13/553,120 · Granted Sep 30, 2014

Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators

Inventors: Christopher Michael Adams (Somerville, MA); Veronique Darsigny (Somerville, MA); Alec Nathanson Flyer (Cambridge, MA); Christine Fang Gelin (San Diego, CA); Timothy Brian Hurley (Boston, MA); Nan Ji (Arlington, MA); Rajeshri Ganesh Karki (Somerville, MA); Toshio Kawanami (Boston, MA); Erik Meredith (Hudson, MA); Chang Rao (Waltham, MA); Michael H. Serrano-Wu (Belmont, MA); Catherine Fooks Solovay (Arlington, MA)
Assignee: Novartis AG
C07D471/04C07D471/08C07D491/044C07D471/10C07D491/107
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Quick Facts
Patent No.
US 8,846,656
App. No.
13/553,120
Granted
Sep 30, 2014
Kind
B2
Abstract

The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Claims (3)

1. A compound, or pharmaceutically acceptable salt thereof, according to the formula:

2. A pharmaceutical composition comprising one or more pharmaceutically acceptable carriers and a therapeutically effective amount of a compound of claim 1 .

3. A method of treating age related macular degeneration comprising administering to a subject in need thereof an effective amount of a composition comprising a compound of claim 1 .

Assignments (11)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 19, 2012
From: HU, BIN
To: NOVARTIS PHARMACEUTICALS CORPORATION
Reel/Frame 029324/0091 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 19, 2012
From: HAR, DENIS; JIANG, XINGLONG; LEE, GEORGE TIEN-SAN
To: NOVARTIS PHARMACEUTICALS CORPORATION
Reel/Frame 029323/0992 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 1, 2012
From: NOVARTIS PHARMACEUTICALS CORPORATION
To: NOVARTIS AG
Reel/Frame 029057/0073 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 1, 2012
From: NOVARTIS PHARMACEUTICALS CORPORATION
To: NOVARTIS AG
Reel/Frame 029057/0249 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2012
From: HAR, DENIS; JIANG, XINGLONG; LEE, GEORGE TIEN-SAN
To: NOVARTIS PHARMACEUTICALS CORPORATION
Reel/Frame 029051/0713 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 30, 2012
From: HU, BIN
To: NOVARTIS PHARMACEUTICALS CORPORATION
Reel/Frame 029051/0721 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 24, 2012
From: NOVARTIS PHARMACEUTICALS CORPORATION
To: NOVARTIS AG
Reel/Frame 029014/0802 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 21, 2012
From: SHEN, LICHUN
To: NOVARTIS PHARMACEUTICALS CORPORATION
Reel/Frame 029006/0749 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2012
From: GELIN, CHRISTINE
To: NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC.
Reel/Frame 028800/0734 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2012
From: NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC.
To: NOVARTIS AG
Reel/Frame 028800/0756 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2012
From: ADAMS, CHRISTOPHER MICHAEL; DARSIGNY, VERONIQUE; FLYER, ALEC; HURLEY, TIMOTHY BRIAN; JI, NAN; KARKI, RAJESHRI GANESH; KAWANAMI, TOSHIO; MEREDITH, ERIK; RAO, CHANG; SERRANO-WU, MICHAEL; SOLOVAY, CATHERINE; TOWLER, CHRISTOPHER; CAPACCI-DANIEL, CHRISTINA
To: NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC.
Reel/Frame 028800/0545 →
Continuity (3)
Provisional Application 61539732 · Sep 27, 2011
Provisional Application 61510643 · Jul 22, 2011
Related Publication 20130184253A1 · Jul 18, 2013