Sulfate esters of noribogaine
Disclosed herein are sulfate esters of noribogaine or 9,17 dihydronoribogaine, and pharmaceutically acceptable salts of each thereof, pharmaceutical compositions comprising such compounds, and methods of their use, including in treating addiction and/or pain.
1. A compound of Formula I:
wherein:
refers to a single or a double bond provided that when is a single bond, Formula I refers to the corresponding dihydro compound;
R is hydrogen or SO 2 OR 2 ;
R 1 is hydrogen or SO 2 OR 2 ;
R 2 is hydrogen or C 1 -C 6 alkyl;
provided that at least one of R and R 1 is not hydrogen;
or a salt thereof.
2. The compound of claim 1 , wherein R 1 is hydrogen.
3. The compound of claim 1 , wherein R 1 is SO 2 OR 2 .
4. The compound of claim 1 , wherein R is hydrogen.
5. The compound of claim 1 , wherein R is SO 2 OR 2 .
6. A pharmaceutical composition comprising a compound of claim 1 and at least one pharmaceutically acceptable excipient.
7. A method for treating pain in a patient which method comprises administering to said patient a therapeutically effective amount of the compound of claim 1 .
8. A method for treating addiction in a patient which method comprises administering to said patient a therapeutically effective amount of the compound of claim 1 .