Granted Patent
B2
US 8,859,604 · App. 14/171,366 · Granted Oct 14, 2014
Crystals and process of making 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid
Inventors:
Luigi Anzalone (West Chester, PA); Frank J. Villani (Perkasie, PA); Christopher A. Teleha (Fort Washington, PA); Penina Feibush (Ambler, PA); Barry Fegely (Quakertown, PA)
Assignee:
Furiex Pharmaceuticals, Inc.
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Abstract
The present invention relates to a novel crystals of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid and methods of making the zwitterion of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1h-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid.
Claims (1)
1. A method of treating a mammal suffering from irritable bowel syndrome, pain or another opioid receptor disorder comprising administering to said mammal an effective amount of a Form β crystal of 5-({[2-amino-3-(4-carbamoyl-2,6-dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy-benzoic acid.
Assignments (7)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 29, 2016
From: FOREST TOSARA LIMITED (F/K/A FOREST TOSARA UNLIMITED COMPANY)
To: ALLERGAN HOLDINGS UNLIMITED COMPANY
Reel/Frame 039897/0440 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 8, 2016
From: FOREST TOSARA UNLIMITED COMPANY
To: ALLERGAN HOLDINGS UNLIMITED COMPANY
Reel/Frame 039370/0273 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 18, 2015
From: FURIEX PHARMACEUTICALS, LLC.
To: FURIEX HOLDINGS UNLIMITED COMPANY
Reel/Frame 036603/0168 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 18, 2015
From: FURIEX HOLDINGS UNLIMITED COMPANY
To: FOREST TOSARA LIMITED
Reel/Frame 036603/0236 →
CHANGE OF NAME
Recorded Sep 18, 2015
From: FURIEX PHARMACEUTICALS, INC.
To: FURIEX PHARMACEUTICALS, LLC.
Reel/Frame 036640/0469 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 25, 2014
From: JANSSEN PHARMACEUTICA N.V.
To: FURIEX PHARMACEUTICALS, INC.
Reel/Frame 032756/0872 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 25, 2014
From: ANZALONE, LUIGI; VILLANI, FRANK J.; TELEHA, CHRISTOPHER A.; FEIBUSH, PENINA; FEGELY, BARRY
To: JANSSEN PHARMACEUTICA, N.V.
Reel/Frame 032756/0861 →
Continuity (5)
Provisional Application
60948584
· Jul 9, 2007