Antitumor agent for undifferentiated gastric cancer
The present invention relates to a therapeutic agent represented by the General formula (I), or a pharmacologically acceptable salt thereof, or a solvate of the compound or the salt thereof: The therapeutic agent comprises a substance having the activity of inhibiting kinase activity of fibroblast growth factor receptor 2 (“FGFR2”). The therapeutic agent can be used for treating undifferentiated gastric cancer, and can also be used to treat organisms comprising a cell overexpressing FGFR2 or a cell expressing mutant FGFR2, or both. The present invention further relates to a pharmaceutical composition comprising an FGFR2 inhibitory and methods of treatment therewith. The present invention also relates to a method for predicting the effect of an FGFR2 inhibitory substance on a patient.
1. A method for treating undifferentiated gastric cancer, characterized by administering, to a patient having undifferentiated gastric cancer, an effective dosage of:
4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide;
or a pharmacologically acceptable salt thereof.
2. A method according to claim 1 , wherein methanesulfonate salt form of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide is administered.
3. A method according to claim 1 , wherein the undifferentiated gastric cancer overexpresses FGFR2 or expresses a mutant FGFR2.
4. A method according to claim 1 , wherein the undifferentiated gastric cancer is at least one gastric cancer selected from the group consisting of poorly differentiated adenocarcinoma, signet-ring cell carcinoma, mucinous carcinoma and scirrhous gastric cancer.