IP Library › Granted Patent US 8,871,781
Granted Patent B2
US 8,871,781 · App. 13/689,398 · Granted Oct 28, 2014

Methods and compositions for treating a subject for a lymphatic malformation

Inventors: Alfred T. Lane (Los Altos, CA); David Berk (St. Louis, MO); Anna L. Bruckner (Centennial, CO); Glenda Louise Swetman (Redwood City, CA)
Assignee: The Board of Trustees of the Leland Stanford Junior University
C07D487/04A61K31/522A61K31/519A61K45/06A61K31/5025
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Quick Facts
Patent No.
US 8,871,781
App. No.
13/689,398
Granted
Oct 28, 2014
Kind
B2
Abstract

Methods of treating lymphatic malformations using a phosphodiesterase type 5 inhibitor are provided. Pharmaceutical compositions and kits comprising phosphodiesterase type 5 inhibitors are also provided.

Claims (5)

1. A method of treating a subject for a lymphatic malformation, the method comprising: administering to the subject an amount of sildenafil effective to treat the subject for the lymphatic malformation.

2. The method according to claim 1 , wherein the sildenafil is administered orally.

3. The method according to claim 1 , wherein the subject weighs 10 kg or less, and the amount of sildenafil administered to the subject is 1 mg/kg.

4. The method according to claim 1 , wherein the subject is a human.

5. The method according to claim 1 , further comprising performing compression, surgical resection, laser ablation, or sclerotherapy to the subject.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 18, 2013
From: LANE, ALFRED T.; BRUCKNER, ANNA L.; BERK, DAVID; SWETMAN, GLENDA LOUISE
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 030032/0798 →
CONFIRMATORY LICENSE Recorded Jan 25, 2013
From: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 029698/0367 →
Continuity (2)
Provisional Application 61565403 · Nov 30, 2011
Related Publication 20130345232A1 · Dec 26, 2013