Compositions and soft tissue replacement methods
The invention relates to compositions comprising a hydrogel material that comprises a glycosaminoglycan polymer, adipose tissue and a compound of the structure The composition is administered to a site of a soft tissue condition including those of breast tissue. The hydrogel material can be porous or of solid particles. The glycosaminoglycan polymer can be a hyaluronan polymer.
1. A composition comprising:
a) an adipose tissue;
b) a hydrogel material comprising a glycosaminoglycan polymer;
c) a compound having the structure of compound 24,
a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable amine salt thereof.
2. The composition of claim 1 , wherein the compound is incorporated into a drug delivery platform comprising a biodegradable polymer matrix.
3. The composition of claim 1 , wherein the hydrogel material is a porous material or solid particles.
4. The composition of claim 1 , wherein glycosaminoglycan polymer is a hyaluronan polymer.
5. A method of treating a soft tissue condition of an individual, the method comprising the step of administering to a site of the soft tissue condition a composition comprising adipose tissue, a hydrogel material comprising a glycosaminoglycan polymer, and a compound, the compound having the structure of compound 24,
a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable amine salt thereof;
wherein administration of the composition promotes formation of a blood supply sufficient to support the transplanted tissue, thereby treating the soft tissue site.
6. The method of claim 5 , wherein the soft tissue condition is a breast tissue condition, a facial tissue condition, a neck condition, a skin condition, an upper arm condition, a lower arm condition, a hand condition, a shoulder condition, a back condition, a torso including abdominal condition, a buttock condition, an upper leg condition, a lower leg condition including calf condition, a foot condition including plantar fat pad condition, an eye condition, or a genital condition.
7. The method of claim 6 , wherein the breast tissue condition is a breast imperfection, a breast defect, a breast augmentation, or a breast reconstruction.
8. The method of claim 6 , wherein the facial tissue condition is a facial imperfection, a facial defect, a facial augmentation, or a facial reconstruction.
9. The method of claim 6 , wherein the facial soft tissue condition is a dermal divot, a sunken cheek, a thin lip, a nasal imperfection or defect, a retro-orbital imperfection or defect, a facial fold, a facial line, a facial wrinkle, or other size, shape or contour imperfection or defect of the face.
10. The method of claim 5 , wherein the soft tissue condition is urinary incontinence, fecal incontinence, or gastroesophageal reflux disease (GERD).
11. A method of treating a soft tissue condition of an individual, the method comprising the steps of
a) administering adipose tissue to a site of the soft tissue condition;
b) administering an effective amount of a hydrogel material comprising a glycosaminoglycan polymer to the site of the soft tissue condition; and
c) administering a compound to the site of the soft tissue condition, the compound having the structure of compound 24,
a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable amine salt thereof;
wherein administration of the compound promotes formation of a blood supply sufficient to support the transplanted tissue, thereby treating the soft tissue site.
12. The method of claim 11 , wherein the glycosaminoglycan polymer is a hyaluronan polymer.
13. The method of claim 11 , wherein the hydrogel material is administered at the same time as, before, or after the compound is administered.
14. The method of claim 11 , wherein the soft tissue condition is a breast tissue condition, a facial tissue condition, a neck condition, a skin condition, an upper arm condition, a lower arm condition, a hand condition, a shoulder condition, a back condition, a torso including abdominal condition, a buttock condition, an upper leg condition, a lower leg condition including calf condition, a foot condition including plantar fat pad condition, an eye condition, or a genital condition.
15. The method of claim 14 , wherein the breast tissue condition is a breast imperfection, a breast defect, a breast augmentation, or a breast reconstruction.
16. The method of claim 14 , wherein the facial tissue condition is a facial imperfection, a facial defect, a facial augmentation, or a facial reconstruction.
17. The method of claim 14 , wherein the facial soft tissue condition is a dermal divot, a sunken cheek, a thin lip, a nasal imperfection or defect, a retro-orbital imperfection or defect, a facial fold, a facial line, a facial wrinkle, or other size, shape or contour imperfection or defect of the face.
18. The method of claim 11 , wherein the soft tissue condition is urinary incontinence, fecal incontinence, or gastroesophageal reflux disease (GERD).