Pharmaceutical compositions for parenteral administration
The invention comprises various aqueous PEG-carbohydrate-lipid based formulations of pharmaceutical active ingredients including compositions for intravenous injections. This invention relates to methods and compositions for improving solubility and the safety profile of pharmaceutical compounds. More particularly, the present invention relates to employing PEG-carbohydrate-lipid conjugates for formulating drug compositions having increased solubility or dispersivity and enhanced stability.
1. A pharmaceutical composition for parenteral administration of a pharmaceutical active ingredient, the composition comprising:
a) an aqueous solution or mixture;
b) a pharmaceutical active ingredient; and
c) a solubility enhancer comprising dioleoylglyceroldiethylenetriamine-monomethoxyl polyethylene glycol ether lactobionate:
wherein:
X 1 , X 2 , X 3 and X i are the same or different linking groups comprising at least one of oxy, amide, succinyl and, carbonyl;
B is a central backbone comprising at least one of glycerol or glycerol-like analogues, polyamine, amino acid, triamine, diethylenetriamine, tetramine, diethylenetetramine, triethylenetetramine, aminoalcohol, and aminopropanediol;
L is a lipid comprising at least one of diacylglycerol, fatty acids, and bile acids;
S is carbohydrate comprising saccharide; and
P is polymer comprising PEG.
2. The pharmaceutical composition of claim 1 comprising the pharmaceutical active ingredient at a concentration between about 0.05 mg/mL and about 50 mg/mL.
3. The pharmaceutical composition of claim 1 comprising a weight ratio of the solubility enhancer to the pharmaceutical active ingredient between about 0.2 and about 25.
4. The pharmaceutical composition of claim 1 comprising a concentration of the polymer-carbohydrate-lipid between about 0.5 percent (w/v) to about 25 percent (w/v).
5. The pharmaceutical composition of claim 1 wherein the pharmaceutical active ingredient is selected from the group consisting of propofol, cisplatin, docetaxel, paclitaxel, posaconazole, voriconazole, and combinations thereof.
6. The pharmaceutical composition of claim 5 wherein the pharmaceutical active ingredient comprises propofol at a concentration in the pharmaceutical composition of between about 0.2 mg/mL to about 25 mg/mL.
7. The pharmaceutical composition of claim 5 wherein the pharmaceutical active ingredient comprises cisplatin at a concentration in the pharmaceutical composition of between about 0.2 mg/mL to about 50 mg/mL.
8. The pharmaceutical composition of claim 5 wherein the pharmaceutical active ingredient comprises docetaxel at a concentration in the pharmaceutical composition of between about 0.2 mg/mL to about 25 mg/mL.
9. The pharmaceutical composition of claim 5 wherein the pharmaceutical active ingredient comprises paclitaxel at a concentration in the pharmaceutical composition of between about 0.2 mg/mL to about 25 mg/mL.
10. The pharmaceutical composition of claim 5 wherein the pharmaceutical active ingredient comprises posaconazole at a concentration in the pharmaceutical composition of between about 0.5 mg/mL to about 40 mg/mL.
11. The pharmaceutical composition of claim 5 wherein the pharmaceutical active ingredient comprises voriconazole at a concentration in the pharmaceutical composition of between about 0.5 mg/mL to about 40 mg/mL.