Use of the endoglycosidase endos for treating immunoglobulin G mediated diseases
The invention provides use of an EndoS polypeptide, or a polynucleotide encoding an EndoS polypeptide, in the manufacture of a medicament for the treatment or prevention of a disease or condition mediated by IgG antibodies.
1. A method of treating or preventing a disease or condition mediated by IgG antibodies in a subject in need thereof, wherein the method of treating the disease or condition comprises administering to the subject a therapeutically effective amount of the polypeptide consisting of SEQ ID NO: 1 and wherein the method of preventing the disease or condition comprises administering to the subject a prophylactically effective amount of the polypeptide consisting of SEQ ID NO: 1.
2. A method of treating, ex vivo, blood taken from a patient suffering from a disease or condition mediated by IgG antibodies, comprising contacting the blood with an EndoS polypeptide.
3. A method according to claim 2 , wherein the blood is returned to the patient after contacting it with said EndoS polypeptide.
4. A method of treating or preventing rheumatoid arthritis in a subject in need thereof, wherein the method of treating comprises administering to the subject a therapeutically effective amount of an EndoS polypeptide and wherein the method of preventing comprises administering to the subject a prophylactically effective amount of an EndoS polypeptide.
5. A method of treating or preventing systemic lupus erythematosus in a subject in need thereof, wherein the method of treating comprises administering to the subject a therapeutically effective amount of an EndoS polypeptide and wherein the method of preventing comprises administering to the subject a prophylactically effective amount of an EndoS polypeptide.
6. A method of treating or preventing idiopathic thrombocytopenic purpura in a subject in need thereof, wherein the method of treating comprises administering to the subject a therapeutically effective amount of an EndoS polypeptide and wherein the method of preventing comprises administering to the subject a prophylactically effective amount of an EndoS polypeptide.
7. A method of treating or preventing allograft or xenograft rejection of a transplant in a subject in need thereof, wherein the method of treating comprises administering to the subject a therapeutically effective amount of an EndoS polypeptide and wherein the method of preventing comprises administering to the subject a prophylactically effective amount of an EndoS polypeptide.