Chemical compound delivery device and method
Devices and methods for delivering a chemical compound to, through or into a membrane, tissue or layer are provided. The device may include an AC signal source and at least one electrode. In one application, an interdigitated electrode may be electrically connected to the AC signal source. In one application, the chemical compound such as a medicament containing a drug may be disposed on or within the electrode and logic may control the AC signal source to provide the signal, including setting or selecting characteristics such as voltage, frequency and the like to orient and/or motivate an amount of the chemical compound through the electrode and into the tissue.
1. A device for motivating a medicament through a membrane comprising:
an alternating current (AC) signal source capable of providing an electric signal having an orienting frequency or an electric signal having a motivating frequency, or both;
at least one non-uniform electrode electrically connected to the AC signal source, where the at least one non-uniform electrode comprises a first irregularly-shaped electrode and a second irregularly-shaped electrode, where the first and second irregularly-shaped electrodes are interdigitated electrodes; where the first and second irregularly-shaped electrodes are electrically connected to the AC signal source; where the first and second irregularly-shaped electrodes define at least one passage to allow an amount of the medicament to pass therethrough; where the first and second irregularly-shaped electrodes describe an equivalent circuit; and where the AC signal source applies an electric signal having an orienting frequency or an electric signal having a motivating frequency, or both, to the equivalent circuit.
2. The device of claim 1 , where the orienting frequency and the motivating frequency are between 0.1 Hz and 20,000 Hz.
3. The device of claim 1 , where the membrane is a biological membrane selected from the group consisting of skin, nail, and tooth tissue, and ocular, buccal, mucosal, vaginal, and rectal membrane.
4. The device of claim 1 , where the medicament comprises a chemical compound selected from the group consisting of ACE inhibitors, steroids, analgesics, anti-coagulants, anti-arthritics, anti-infectives, anti-convulsants, anti-depressives, anti-fungals, anti-hypertensives, anti-psychotics, antihistamines, beta blockers, dermatologics, polypeptides, polynucleotides, NSAIDS, ocular drugs, hormones, and urology drugs, and any combination thereof.
5. The device of claim 1 , where the first and second non-uniform electrodes are spaced apart from each other by an insulating layer having interstitial areas sufficient to allow an amount of the medicament to pass therethrough.
6. A patch for delivering a drug across a membrane, the patch comprising:
connections for receiving an electrical signal having a motivating frequency, an orienting frequency, or both from an alternating current (AC) electrical power source;
a bandage;
a distal electrode disposed between the bandage and the membrane and adapted to be electrically connectable to at least one of the connections;
at least one non-uniform electrode disposed proximate the distal electrode and the membrane, where the at least one non-uniform electrode comprises a first irregularly-shaped electrode and a second irregularly-shaped electrode, where the first and second irregularly-shaped electrodes are interdigitated electrodes; and where the first and second irregularly-shaped electrodes are each electrically connectable to respective ones of the connections;
medicament disposed between the distal electrode and the at least one non-uniform electrode, the medicament comprising at least one drug;
where the first and second irregularly-shaped electrodes define at least one passage to allow an amount of the at least one drug to pass therethrough;
where the distal electrode and the at least one non-uniform electrode describe a first equivalent circuit; and
where the connections apply an electrical signal having an orienting frequency or an electric signal having a motivating frequency, or both, to the first equivalent circuit.
7. The patch as claimed in claim 6 , where the at least one non-uniform electrode comprises a first and second non-uniform electrodes that are spaced apart from each other by an insulating layer having interstitial areas sufficient to allow an amount of the at least one drug to pass therethrough.
8. The patch as claimed in claim 7 , where a second equivalent circuit is described by the first and second irregularly-shaped electrodes, and where the connections apply an electrical signal having an orienting frequency or an electric signal having a motivating frequency, or both, to the second equivalent circuit.
9. The patch as claimed in claim 7 , where a second equivalent circuit is described by the first and second non-uniform electrodes, and where the connections apply an electrical signal having an orienting, frequency or an electric signal having a motivating frequency, or both, to the second equivalent circuit.
10. The patch as claimed in claim 7 , comprising a second equivalent circuit, and where the connections apply an electrical signal having an orienting frequency or an electrical signal having a motivating frequency, or both, to the second equivalent circuit.
11. The patch as claimed in claim 6 , where the medicament is selected from the group consisting of ACE inhibitors, steroids, analgesics, anti-coagulants, anti-arthritics, anti-infectives, anti-convulsants, anti-depressives, anti-fungals, anti-hypertensives, anti-psychotics, antihistamines, beta blockers, dermatologics, polypeptides, polynucleotides, NSAIDS, ocular drugs, hormones, and urology drugs, and any combination thereof.