Ricin ribosome binding protein compositions and methods of use thereof
View Patent ↗Compositions and methods for treatment of toxin poisoning are disclosed.
1. A mutant ricin toxin that is mutated relative to the wild type ricin A chain toxin of SEQ ID NO: 1, wherein the mutations are selected from the group consisting of i) RI89A and R234A; ii) RI93A and R235A; iii) RI93A and R235A and RI89A; iv) RI93A and R235A and R234A; v) RI93A and R235A and RI89A and R234A; and vi) R213A and R258A.
2. The mutant ricin toxin claim 1 , wherein the mutations are RI89A and R234A.
3. The mutant ricin toxin claim 1 , wherein the mutations are RI93A and R235A.
4. The mutant ricin toxin claim 1 , wherein the mutations are RI93A, R235A and RI89A.
5. The mutant ricin toxin claim 1 , wherein the mutations are RI93A, R235A and R234A.
6. The mutant ricin toxin claim 1 , wherein the mutations are RI93A, R235A, RI89A and R234A.
7. The mutant ricin toxin claim 1 , wherein the mutations are R213A and R258A.
8. A composition comprising a mutant ricin toxin of claim 1 and a biologically acceptable carrier.
9. A method of eliciting an immune response to ricin A chain toxin, comprising administering to an animal at least one mutant ricin toxin of claim 1 in an amount effective to elicit an immune response to ricin A chain toxin.